Imaging disease activity in patients with Graves' orbitopathy using [18F]-FDG-PET/CT - a pilot study
Completed
- Conditions
- Graves' orbitopathyThyroid-associated eye disease100437391002187710003816
- Registration Number
- NL-OMON38026
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 9
Inclusion Criteria
> 18 years old and signed informed consent
Patients with Graves' orbitopathy (3 groups: higly active / moderately active / completely inactive)
Euthyroid >= 2 months
Exclusion Criteria
Pregancy
Uncontrolled diabetes mellitus, or hyperglycemia prior to scan
For patients with active disease: currently receiving treatment for orbitopathy, or treatment ended < 3 months before entry
For patients with completely inactive disease: history of surgical decompression treatment
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Qualitative assessment of [18F]-FDG uptake in orbital tissue as imaged by the<br /><br>PET/CT scan and comparison of data between subjects (or groups)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Semi-quantitative analysis of [18F]-FDG uptake as imaged by the PET/CT scan (a<br /><br>standardized uptake value (SUV) is calculated)<br /><br>Clinical Activity Score</p><br>