Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men

Not Applicable

Suspended

• Conditions: Metabolic Syndrome; Insulin Resistance; Obesity
• Interventions: Behavioral: Exercise

• Registration Number: NCT01962857
• Lead Sponsor: University of Glasgow

Brief Summary

A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-10-08
• Study First Submitted QC: 2013-10-10
• Study First Posted: 2013-10-14
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-02
• Last Update Posted: 2016-06-03
• Primary Completion: 2017-07
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• male
• 18-40 years
• undertaking < 1 hour per week of planned exercise

Exclusion Criteria

• BMI > 35 kg/m2
• Blood pressure > 160/90 mm Hg (on anti-hypertensive medication)
• history of established coronary heart disease
• family history of early cardiac death (<40 years)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	4 week supervised high-intensity shuttle running intervention, with 3 sessions per week (12 sessions in total)

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	Change from baseline immediately post-intervention (4 weeks after baseline)	Assessed from glucose and insulin concentrations in fasted state and during oral glucose tolerance test.

Secondary Outcome Measures

Name	Time	Method
Resting substrate utilization	Change from baseline immediately post-intervention (4 weeks after baseline)	Metabolic rate and fat and carbohydrate oxidation estimated via indirect calorimetry
Endurance exercise performance	Change from baseline immediately post-intervention (4 weeks after baseline)	Time taken to complete 100 x 10m shuttle runs
Sprint exercise performance	Change from baseline immediately post-intervention (4 weeks after baseline)	Time taken to complete 10 x 10m shuttle runs
Body weight	Change from baseline immediately post-intervention (4 weeks after baseline)
Waist circumference	Change from baseline immediately post-intervention (4 weeks after baseline)
Percentage body fat	Change from baseline immediately post-intervention (4 weeks after baseline)
Clustered Cardiometabolic Risk Score	Change from baseline immediately post-intervention (4 weeks after baseline)	Clustered Cardiometabolic Risk Score = -zHDL+zInsulin+zGlucose+zTriglycerides+( zBMI+zWC)/2+(zSBP+zDBP)/2.

Trial Locations

Locations (1)

University of Glasgow; 🇬🇧 Glasgow, United Kingdom