Ruolo Del Desametasone Per il Controllo Multimodale Del Dolore Postoperatorio in Chirurgia Toracica
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Morphine consumption
研究概览
简要总结
The aim of the study is to evaluate the analgesic properties of dexamethasone and to quantify the possible associated postoperative complications, such as wound infections and hyperglycaemia, in patients who underwent lobectomy, segmentectomy or atypical resection surgery with a mini-thoracotomy approach or video-assisted thoracoscopic surgery (VATS).
详细描述
We designed an observational study, aimed to evaluate the possible reduction in morphine consumption in thoracic patients, who were administered dexamethasone compared to who didn't received the drug.
The research wants to assess the presence of additional analgesic properties, besides the well known antiemetic effect, in the intraoperative administration of dexamethasone, and the possible postoperative complications, such as wound infections and hyperglycaemia.
The rational is to ameliorate the anaesthesiological management, in particular with a view to a opioid-sparing analgesia in thoracic patients.
To do so, we enrolled thoracic patients, who underwent elective lobectomy, segmentectomy or atypical resection surgery with a mini-thoracotomy approach or video-assisted thoracoscopic surgery (VATS).
We selected two groups: one in which patients were administered dexamethasone 8 mg at the moment of induction, and the other one in which patients didn't received dexamethasone, but ondansetron 4 mg at the end of surgery. Both groups received other antiemetic drugs based on Apfel score and multimodal analgesia, comprising loco-regional analgesia, opioids and other analgesic drugs administration.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI < 30 kg/m2
- •ASA I-III
- •Lobectomy, segmentectomy or atypical resection surgery with a mini-thoracotomy approach or VATS
排除标准
- •Refusal by the patient to participate or patient unable to express his own consent
- •Chronic therapy with medium-high doses of corticosteroids
- •Chronic therapy with opioids
- •METS ≤ 4, defining an overall decreased cardiovascular fitness
- •Urgent or emergency surgery
- •Allergy to the active ingredient of the drug used
- •Kidney failure at stage III or more
- •Liver failure
- •Pregnancy
- •Drug addiction, patients with a history of drug abuse
- •Corrected Qt interval (QTc) > 0,45 for males and 0,47 for women
研究组 & 干预措施
Dexamethasone group
Group of patients receiving dexamethasone 8 mg as part of the multimodal analgesia.
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Morphine consumption
时间窗: 24 hours after surgery
Morphine dose, in milligrams, administered in the 24 hours after the surgery
次要结局
- Static and dynamic Numeric Rating Scale (NRS)(24 hours after surgery)
研究者
Marzia Umari
Principal Investigator
University of Trieste