A Psoriasis Plaque Test Comparing Products for the Treatment of Psoriasis Vulgaris
Phase 1
Completed
- Conditions
- Psoriasis Vulgaris
- Interventions
- Drug: Combination of clobetasol propionate plus calcipotriol ointment, clobetasol propionate ointment, calcipotriol ointment, and the ointment vehicle
- Registration Number
- NCT01043224
- Lead Sponsor
- LEO Pharma
- Brief Summary
The purpose of this trial is to compare the anti-psoriatic effect of a topical combination product containing clobetasol propionate and calcipotriol in an ointment formulation to the single components in the same vehicle using a psoriasis plaque test design.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Clobetasol propionate plus calcipotriol Combination of clobetasol propionate plus calcipotriol ointment, clobetasol propionate ointment, calcipotriol ointment, and the ointment vehicle -
- Primary Outcome Measures
Name Time Method Total Clinical Score of clinical symptoms 3 weeks
- Secondary Outcome Measures
Name Time Method Clinical scores, lesions thickness, NIR spectroscopic measurements 3 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which clobetasol propionate and calcipotriol synergistically treat psoriasis vulgaris?
How does the combination of clobetasol propionate and calcipotriol compare to standard-of-care topical treatments for psoriasis in terms of efficacy and safety?
Which biomarkers are associated with response to glucocorticoid and vitamin D analog combination therapy in psoriasis vulgaris?
What are the potential adverse events of clobetasol propionate plus calcipotriol ointment and how do they compare to monotherapy regimens?
Are there alternative combination therapies to clobetasol and calcipotriol for psoriasis vulgaris that show improved therapeutic outcomes?
Trial Locations
- Locations (1)
LEO Pharma investigational site
🇫🇷Nice, France
LEO Pharma investigational site🇫🇷Nice, France