Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging

Overview

Registry

who.int

Start Date

January 10, 2019

End Date

January 5, 2015

Last Updated

3 years ago

Study Type

Interventional

Sex

All

Sponsor

•Stroke patients with aphasia:
•1\. First occurrence of cerebral infarction or hemorrhage
•2\. Aged 35–70 years
•3\. Disease course lasting for 3–24 months
•4\. Right\-handed according to the Edinburgh Handedness Inventory
•5\. Educated beyond primary school (more than 5 years of education)
•6\. Aphasia determined by Western Aphasia Battery (WAB) (aphasia quotient \<93\.8\)
•7\. No obvious attention, memory, and visuo\-spatial function disturbances (Non\-language cognitive function assessment scale, 2013 \>70\)
•8\. Retaining part of the auditory ability and tolerance of more than 30 minutes to complete the daily training task
•Healthy participants:

•Stroke patients with aphasia:
•1\. Frenchay dysarthria assessment shows moderate to severe dysarthria
•2\. Serious speech apraxia or oral and maxillofacial apraxia
•3\. Anxiety determined by Hamilton Anxiety Scale or depression determined by Hamilton Depression Scale
•4\. Obvious dyssomnia or emotional disturbances
•5\. Other diseases likely to aggravate patient’s functional status such as cancer, severe heart or lung disease
•6\. Refused training or no desire for training
•7\. Severe pain, i.e. pain \>8 out of 10 on a visual analog scale (VAS)
•Healthy participants:
•7\. Poor physical condition for any reason