Prone and Oscillation Pediatric Clinical Trial - PROSpect

ational Heart, Lung and Blood Institute0 个研究点目标入组 36 人开始时间: 待定最近更新: 2024年4月15日

试验速览

暂无简介。

•Pediatric patients >=2 weeks of age (>=42 weeks post gestational age) and <18 years of age*Intubated and mechanically ventilated with severe PARDS for <48 hours per PALICC guidelines(chest imaging consistent with acute pulmonary parenchymal disease and OI >=16 or OSI >=12.3). We require two consecutive blood gases meeting severe PARDS criteria (separated by at least 4 hours during which time the clinical team is working to recruit lung volume and optimize the patient*s hemodynamic status per PALICC guidelines).

•Perinatal related lung disease
•Congenital diaphragmatic hernia or congenital/acquired diaphragm paralysis
•Respiratory failure explained by cardiac failure or fluid overload, cyanotic heart disease, cardiomyopathy
•Unilateral lung disease*Primary pulmonary hypertension
•Status asthmaticus
•Obstructive airway disease (e.g.,bronchiolitis or disease states characterized by either: hypercapnia with FiO2< 0.30, and/or evidence of increased resistance visible on the flow -time scalar, and/or presence of intrinsicPEEP)*Bronchiolitis obliterans
•Post Hematopoietic Stem Cell transplant
•Post lung transplant
•Home ventilator (including noninvasive) or home oxygen dependent
•Neuromuscular respiratory failure
•Critical airway (e.g., post laryngotracheal surgeryor new tracheostomy) or anatomical obstruction of the lower airway (e.g., mediastinal mass)
•Facial surgeryor trauma in previous 15 days
•Headtrauma, intracranial bleeding
•Unstable spine, femur or pelvic fractures
•Acute abdominal process
•Obesity (2w-2y: weight-for-height z-score >+3 WHO; >2y BMI z score >+2 WHO)
•Received either prone positioning or HFOV with current illness, supported on ECMO
•Previously enrolled in current study
•Family/medical team not providingfull support (patient treatment considered futile)
•Enrolled in any other critical care interventional clinical trial concurrently
•Known pregnancy

发起方

ational Heart, Lung and Blood Institute