Magnetic Resonance Imaging of Brain Development in Autism

UMC Utrecht1 site in 1 country300 target enrollmentJanuary 2006

ConditionsAutism

Overview

Phase: N/A
Intervention: Not specified
Conditions: Autism
Sponsor: UMC Utrecht
Enrollment: 300
Locations: 1
Last Updated: 19 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.

Registry

clinicaltrials.gov

Start Date

January 2006

End Date

TBD

Last Updated

19 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

UMC Utrecht

Eligibility Criteria

Inclusion Criteria

•Aged 6 - 18 years at initial MRI
•Inclusion criteria for subjects with autism
•DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview
•Inclusion criteria for controls
•no DSM-IV (APA, 1994) diagnosis, according to DISC interview
•no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Exclusion Criteria

•major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
•presence of metal objects in or around the body (pacemaker, dental braces)
•history of or present neurological disorder
•for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based