When and How to Administer Oxytocin for Active Management of Third Stage of Labour
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- postpartum bleeding in the third stage of labour
研究概览
简要总结
To compare the efficacy of the route and timing of oxytocin administration for Active management of third stage of labour (AMTSL).
详细描述
Our objective is to determine the most efficient route and timing of oxytocin administration by measuring the duration of third stage of labour, quantitative blood during the first hour after delivery and comparing haemoglobin and haematocrit changes and the need for additional interventions in patients who had either a spontaneous labour or received labour augmentation with oxytocin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 盲法
- Single (Participant)
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •having a singleton pregnancy above 37th gestational week
- •normal live vaginal delivery with cephalic presentation
- •being in active labor
排除标准
- •Fetal demise
- •multiple pregnancy
- •known coagulation disorder
- •presentation anomalies
- •placental pathology
- •liver disease
- •thrombocytopenia
- •hypertension or being currently on anticoagulants
- •having a cesarean section, operative delivery or deep vaginal tear
- •chorioamnionitis
- •developing HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) or DIC (disseminated intravascular coagulation) before delivery
研究组 & 干预措施
intravenous & intramuscular oxytocin
intravenous or intramuscular 10 iu oxytocin
干预措施: after delivery of the fetus & when anterior shoulder seen (Procedure)
after delivery & when anterior shoulder seen
oxytocin 10 iu after the delivery of the fetus or when the anterior shoulder was seen after the fetal head was delivered
干预措施: intravenous & intramuscular oxytocin (Drug)
结局指标
主要结局
postpartum bleeding in the third stage of labour
时间窗: participants will be followed for the duration of hospital stay, an expected average of 48 hours
次要结局
未报告次要终点
研究者
SEZİN ERTURK AKSAKAL
gynecologist and obstetrician
Etlik Zubeyde Hanim Womens' Health and Teaching Hospital