Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis of Suspected Lung Cancer & Staging of Concurrent Mediastinal Lymphadenopathy at Ain-Shams University Hospitals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Comparing the diagnostic accuracies of both EBUS TBNA and FDG-PET /CT
研究概览
简要总结
Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis. Fludeoxyglucose-18 (FDG) positron emission tomography (PET) combined with low dose contrast computed tomography (CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are two diagnostic modalities widely used in the field of staging & diagnosis of lung malignancies, the former depends on image analysis while the later enables real-time sampling of lymph nodes under sonographic guidance with concurrent cytological examination. The present research aims to compare the diagnostic and staging accuracies of (EBUS-TBNA) versus FDG-PET /CT as two diagnostic modalities in patients with suspected lung malignancies. However as a secondary outcome this study aims at monitoring the possible complications arising post EBUS-TBNA procedure.
详细描述
Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis. Fludeoxyglucose-18 (FDG) positron emission tomography (PET) combined with low dose contrast computed tomography (CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are two diagnostic modalities widely used in the field of staging & diagnosis of lung malignancies, the former depends on image analysis while the later enables real-time sampling of lymph nodes under sonographic guidance with concurrent cytological examination.
Objective
To compare the diagnostic and staging accuracy of convex probe EBUS-TBNA versus FDG - PET/CT as two diagnostic modalities in diagnosis of suspected lung cancer & staging of concurrent mediastinal lymphadenopathy Patients and Methods: This prospective, interventional cohort research was performed on 40 cases with suspected lung malignancies. All cases were examined via FDG-PET/CT followed by convex probe EBUS-TBNA for diagnosis of suspected lung cancer & staging of concurrent mediastinal lymphadenopathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years old or more.
- •Patients presented with centrally located suspiciously malignant lung masses with or without lymphadenopathy.
- •patients with mediastinal lymphadenopathy only as evident by contrast - enhanced CT scan of the chest.
- •patients with peripheral lung malignancy and mediastinal lymphadenopathy who were referred for MLN staging were also recruited to the research
排除标准
- •All patients who were who were unfit for bronchoscopy as per international guidelines for practice.
- •Cases are diagnosed with stage IV (metastatic) lung cancer.
- •Patients with histopathological diagnosis other than malignancy (as Sarcoidosis, Tuberculosis).
- •patients unfit for FDG-PET G-PET/CT examination (uncontrolled Hyperglycemia, renal impairment).
- •Patients who refused to participate to the study.
结局指标
主要结局
Comparing the diagnostic accuracies of both EBUS TBNA and FDG-PET /CT
时间窗: 2 years
Comparing the diagnostic yield of both modalies as they are considered primary main diagnostic and staging modalities for lung malignancies
Comparing the staging accuracies of both convex probe EBUS-TBNA versus FDG - PET/CT
时间窗: 2 years
Accurate staging of lung malignancies is considered crucial in determining the prognosis and specifying the treatment plan.
次要结局
- Determine the complications(2 years)
研究者
Fatma Alzahraa
Assistant lecturer of pulmonology
Ain Shams University