A Comparative Study Evaluating Efficacy Of Combination Therapy Of Intralesional Triamcinolone Acetonide With Fractional CO2 Laser Versus Intralesional Triamcinolone Acetonide With Hyaluronidase In Management Of Keloids

A comparative study will be carried out at Parul Sevashram hospital which is attached to Parul Institute of Medical Sciences and Research, Parul University, Vadodara on patients presenting with keloids to the outpatient department of Dermatology, venereology and Leprosy and referred from medicine & surgery department. The study will start after taking permission from Institutional Ethics Committee and allotment of CTRI registration number. 

1. All patients meeting the inclusion and exclusion criteria will be subjected to detailed history and meticulous examination as per proforma after taking informed consent.

 2. Group A (study group): treated with fractional CO2 laser followed by intralesional triamcinolone acetonide. Fractional CO2 laser therapy is given with energy 10-30mJ, depending on scar thickness. Triamcinolone is injected immediately after laser therapy. Sessions every 3 weeks for 4 sessions.

 Group B (study group): treated with hyaluronidase injection along with triamcinolone acetonide: typically 1500 IU equivalent to 50 IU per 1 ml of steroid solution is given intralesionally. Given every 3 weeks for 4 sessions.

 3. Patient will be observed for thirty minutes after completion of procedure. Follow up after 3 months to check for degree of reduction and again after 6 months to check for recurrence.