Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hematopoietic/Lymphoid Cancer
- Sponsor
- Rutgers, The State University of New Jersey
- Locations
- 1
- Status
- Withdrawn
- Last Updated
- 10 years ago
Overview
Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.
Detailed Description
OBJECTIVES: Primary * Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers. Secondary * Determine complications of radiation therapy for patients undergoing radiation therapy for cancer. OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified