Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change in Biochemical parameters
研究概览
简要总结
Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.
详细描述
Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.
Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •older than 18 years undergoing elective endovascular aortic repair
- •who have signed informed consent
排除标准
- •urgent surgery
- •with known hypersensitivity to Desflurane or Sevoflurane.
- •Renal failure in hemodialysis
研究组 & 干预措施
Group sevoflurane
Administration under labelling conditions
干预措施: Sevoflurane (Drug)
Group desflurane
Administration under labelling conditions
干预措施: Desflurane (Drug)
结局指标
主要结局
Change in Biochemical parameters
时间窗: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
osmolarity(mOsm/Kg) in urine
次要结局
- Need for postoperative mechanical ventilation(24 hours)
- ICU length of stay(up to 24 hours)
- anesthetic recovery(These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. timeframe 1 hour(stimated))
研究者
Begoña Quintana Villamandos
Anesthesiologsit
Hospital General Universitario Gregorio Marañon