NL-OMON41007
Withdrawn
Not Applicable
Identifying genetic determinants of Familial Barrett*s esophagus and adenocarcinoma of the gastro-esophageal junction - IFAMBAR study
Maag-, Darm- en Leverziekten0 sites60 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- adenocarcinoma of the gastro-esophageal junction
- Sponsor
- Maag-, Darm- en Leverziekten
- Enrollment
- 60
- Status
- Withdrawn
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •As described earlier, we identified in a collaborative effort (with the Departments of Surgery and Medical Genetics) 20 index patients from families that fulfill the criteria for familial BE or adenocarcinoma of the GEJ. Apart from the retrospectively identified index patient, new index patients identified during this study by the department of Medical Genetics will also be eligible for this study,;The criteria for familial BE or adenocarcinoma of the GEJ:
- •A. Two or more first\- or second degree relatives with BE or adenocarcinoma of the GEJ, with at least one diagnosed before the age of 50
- •B. Three or more first\- or second degree relatives with BE or adenocarcinoma of the GEJ, irrespective of age
- •C. One patient with BE or adenocarcinoma of the GEJ \< 40 yrs;For this study, individuals that meet the following inclusion criteria are eligible:
- •All first degree relatives (i.e. sons, daughters, sisters, brothers and father and mother of the index patient) of the index patient
Exclusion Criteria
- •A potential individual who meets any of the following criteria will be excluded from participation in this study:
- •1\) Individuals \< 25 and \> 75 years old
- •2\) Unable to fill out questionnaire
Outcomes
Primary Outcomes
Not specified
Similar Trials
Not yet recruiting
Not Applicable
Familial Barrett's EsophagusNL-OMON22205niversity Medical Center Utrecht60
Recruiting
Not Applicable
Molecular genetic analysis of patients with Bernard Soulier syndromeD69.1Qualitative platelet defectsDRKS00004372ZLB Behring GmbH20
Not yet recruiting
Not Applicable
Predisposing genetic risk factors for Barrett*s EsophagusBarretts esophaguscell abnormality in the lower esophagus10017934NL-OMON39802Erasmus MC, Universitair Medisch Centrum Rotterdam600
Completed
Not Applicable
Exploratory Study of Genetic Factors Related to the Inhibitory Effect of Tolvaptan on Increased Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney DiseaseAutosomal Dominant Polycystic Kidney DiseaseJPRN-UMIN000031976Otsuka Pharmaceutical Co.,Ltd.890
Completed
Not Applicable
Identification of the genetic pathways involved in patients overreacting to radiotherapyNL-OMON35606MAASTRO clinic6