Identifying genetic determinants of Familial Barrett*s esophagus and adenocarcinoma of the gastro-esophageal junction - IFAMBAR study

Maag-, Darm- en Leverziekten0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•As described earlier, we identified in a collaborative effort (with the Departments of Surgery and Medical Genetics) 20 index patients from families that fulfill the criteria for familial BE or adenocarcinoma of the GEJ. Apart from the retrospectively identified index patient, new index patients identified during this study by the department of Medical Genetics will also be eligible for this study,;The criteria for familial BE or adenocarcinoma of the GEJ:
•A. Two or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, with at least one diagnosed before the age of 50
•B. Three or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, irrespective of age
•C. One patient with BE or adenocarcinoma of the GEJ < 40 yrs;For this study, individuals that meet the following inclusion criteria are eligible:
•All first degree relatives (i.e. sons, daughters, sisters, brothers and father and mother of the index patient) of the index patient

•A potential individual who meets any of the following criteria will be excluded from participation in this study:
•1) Individuals < 25 and > 75 years old
•2) Unable to fill out questionnaire

发起方

Maag-, Darm- en Leverziekten