Effects of Bariatric Surgery on Inspiratory Metaboreflex in Metabolically Healthy Obese and Obese Subjects With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Inspiratory metaboreflex
研究概览
简要总结
The hypothesis of this study is that reductions in body weight could improve inspiratory muscle function attenuating the inspiratory metaboreflex in metabolically healthy obese individuals and obese individuals with metabolic syndrome.
详细描述
Introduction
Peripheral metaboreflex activation appears to be exacerbated in obese individuals with metabolic syndrome. Interestingly, bariatric surgery attenuates the peripheral metaboreflex. Obese individuals have impaired inspiratory muscle function, which can be reversed by the reduction in body weight. Therefore, bariatric surgery could attenuate inspiratory metaboreflex in metabolically healthy obese individuals and obese individuals with metabolic syndrome. Objectives: To investigate the effects of bariatric surgery on inspiratory metaboreflex in metabolically healthy obese individuals and in obese patients with metabolic syndrome. Patients and Methods: A sample comprising of 15 obese subjects with metabolic syndrome, 15 obese subjects without metabolic syndrome and 15 healthy nonobese individuals. These subjects will be submitted to pulmonary function, respiratory muscle strength, inspiratory muscle resistance, exercise tolerance, quality of life, autonomic cardiovascular control and the inspiratory metaboreflex evaluation. The evaluations performed in obese patients with and without metabolic syndrome pre-surgery will be repeated 6 months after bariatric surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Body mass index (BMI)> 35 kg / m²
- •Diagnosis of metabolic syndrome
排除标准
- •Acute health problems in the last month (viral or bacterial infections, accidents, allergic reactions)
- •Diseases of the nervous system or conditions that affect the understanding or participation in the study
- •Pregnancy
- •Type I diabetes mellitus
- •Arterial hypertension
- •Dyslipidemias
- •Coronary artery disease
- •Left ventricular dysfunction
- •Any condition interfering with locomotion
- •Bronchial asthma
- •Chronic obstructive pulmonary disease
- •Chronic neuropathies
- •Use of drugs such as corticosteroids or bronchodilators
- •Obese without Metabolic Syndrome
- •Inclusion Criteria:
- •Body mass index (BMI)> 35 kg / m²
- •Exclusion Criteria:
- •Metabolic Syndrome
- •Acute health problems in the last month (viral or bacterial infections, accidents, allergic reactions)
- •Diseases of the nervous system or conditions that affect the understanding or participation in the study
- •Pregnancy
- •Type I diabetes mellitus
- •Arterial hypertension
- •Dyslipidemias
- •Coronary artery disease
- •Left ventricular dysfunction
- •Any condition interfering with locomotion
- •Bronchial asthma
- •Chronic obstructive pulmonary disease
- •Chronic neuropathies
- •Use of drugs such as corticosteroids or bronchodilators
- •Healthy nonobese subjects
- •Inclusion Criteria:
- •BMI <25 kg / m²
- •Exclusion Criteria:
- •Non-smokers
- •Any diagnosed disease.
结局指标
主要结局
Inspiratory metaboreflex
时间窗: 6 monhs
It will be induced through a linear inspiratory resistance of 60% of maximal inspiratory pressure
次要结局
- Inspiratory muscle resistance(6 months)
- Autonomic cardiovascular control(6 months)
- Exercise tolerance(6 months)
- Quality of life(6 months)
- Pulmonary function(6 months)
- Respiratory muscle strength(6 months)