The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Not Applicable
Completed
- Conditions
- Ischaemic Heart Diseases
- Interventions
- Procedure: Forearm vascular study
- Registration Number
- NCT00789243
- Lead Sponsor
- University of Edinburgh
- Brief Summary
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- Healthy males between 18-65 years of ages, non-smokers.
Exclusion Criteria
- Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 1 Forearm vascular study Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, local ischaemic preconditioning will be induced by inflating a cuff around the non-dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times. 2 Forearm vascular study Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, remote ischaemic preconditioning will be induced by inflating a cuff around the dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times. 3 Forearm vascular study Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, sham will be performed by inflating a cuff to 10 mmHg for 5 mins followed by 5 mins of deflation. This cycle will be repeated 3 times.
- Primary Outcome Measures
Name Time Method Net t-PA release from the endothelium after ischaemia reperfusion and ischaemic preconditioning Throughout the study
- Secondary Outcome Measures
Name Time Method Change in forearm blood flow after ischaemia reperfusion and ischaemic preconditioning throughout the study Change in platelet-monocyte-binding after ischaemia reperfusion and ischaemic preconditioning Throughout the study
Trial Locations
- Locations (1)
University of Edinburgh, 49 Little France Crescent
🇬🇧Edinburgh, United Kingdom