Steroid in alcoholic hepatitis
Not Applicable
- Conditions
- Health Condition 1: K701- Alcoholic hepatitis
- Registration Number
- CTRI/2023/03/050521
- Lead Sponsor
- AIG Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
WIth MELD score >21 and/or mDF >32
Patients with infection at baseline will be included if they have controlled infection.
Exclusion Criteria
1)Age < 18 years, > 70 years
2)Active Infection
3)Acute Kidney Injury (creatinine >1.5 mg/dl)
4)Recent / ongoing bleed
5)Active peptic ulcer disease
6)Hepatocellular carcinoma, portal vein thrombosis or hepatic venous outflow tract obstruction
7)Patients with concomitant other liver diseases including hepatitis B, C, NAFLD
8)Patients with HIV
9)Patients who are no willing to provide consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the incidence of infectionTimepoint: at day 28 and day 90
- Secondary Outcome Measures
Name Time Method Change in severity scoreTimepoint: in both groups - at Day 4,Day 7,Day 28 and Day 90;Compare the adverse events in each groupTimepoint: At Day 90;Compare the incidence of acute kidney injury in each groupTimepoint: At Day 90;Compare the incidence of mortalityTimepoint: at 90 days in both the groups;Compare the number of <br/ ><br>responders in both the groupsTimepoint: At Day 7;Compare the source, site, and outcomes of infectionTimepoint: At Day 90;To compare the proportion of patients requiring readmissions in each groupTimepoint: at day 90