NCT06911931招募中不适用
Visual Perception in Schizophrenia: Assessing Predictive Processing in the Earliest Stages of the Visual Cortical Hierarchy
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- mean amplitude of EEG visual response
研究概览
简要总结
This study aims to identify novel markers of psychosis using electroencephalography (EEG).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All Subjects
- •Aged 18-65
- •20/32 visual acuity or better (using in-house optical correction, if necessary)
- •An ability to speak English well enough to complete study assessments and to consent to the study
- •Subjects with Schizophrenia-Spectrum Disorder
- •Meets DSM-5 diagnostic criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder as confirmed by the Structured Interview for DSM-5 (SCID-5).
- •Subjects with Bipolar Disorder
- •Meets DSM-5 diagnostic criteria for bipolar disorder (type I, II, or unspecified) as confirmed by the Structured Interview for DSM-5 (SCID-5).
排除标准
- •All subjects
- •Presence of characteristics that could impair one's ability to comprehend the nature of the study, provide informed consent, or understand the assessment questions, including the following:
- •Subject cannot read and understand the instructions well enough to complete the tasks or cannot provide informed consent.
- •Intellectual impairment (WRAT-5 score < 70) (at the discretion of experimenter);
- •Actively intoxicated, as shown via patient self-report or staff report;
- •Substance use disorder in the past 3 months;
- •Subject considered high risk for suicidal acts (i.e., active suicidal ideation as determined by clinical interview OR any suicide attempt in 30 days prior to screening);
- •Subject violence (involving severe/lethal means or violence occurring in prior 6 months) or extreme agitation.
- •Being in a current manic state
- •Head injury with loss of consciousness greater than 10 minutes (at the discretion of the experimenter).
- •Subject has had electroconvulsive therapy (ECT) in the past 8 weeks;
- •Diagnosed with a neurological condition (tumor, stroke, brain injury) or neurological disorder, including seizure disorders. Diagnosed with pervasive developmental disorder (phone screen or medical records)
- •Lazy eye or squint or other known ocular pathology
- •Healthy Control Subjects
- •Any lifetime psychotic disorder or history of psychiatric hospitalization (self disclosure);
- •Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days (self-disclosure); iii. First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
- •Case-match Control Non-ill Subjects
- •Any lifetime psychotic disorder (as assessed by SCID/or SSD);
- •Recurrent depressive episodes or being in a current depressive episode (as assessed by SCID/or SSD)
- •Persistent threshold psychotic symptoms
- •History of psychiatric hospitalization;
- •Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days
- •First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
- •Bipolar Subjects
- •Persistent threshold psychotic symptoms
研究组 & 干预措施
All participants
Experimental
干预措施: EEG measure of visual processing (Other)
结局指标
主要结局
mean amplitude of EEG visual response
时间窗: Day 1
次要结局
未报告次要终点
研究者
Edmund Lalor
Associate Professor
University of Rochester
研究点 (1)
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