Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy
Not Applicable
Completed
- Conditions
- Glomerulonephritis, IGA
- Registration Number
- NCT00521508
- Brief Summary
Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- Patients with pathogenesis of Berger's disease confirmed by renal biopsy
- Glomerular filtration > 60 ml/min/1,73m2
- Written informed consent
- Patient affiliated to social insurance
Exclusion Criteria
- Immunosuppressor treatment within 6 months before the study inclusion
- Clinical infection within 2 months before the study inclusion
- C-reactive protein (CRP) > 10 mgL-1
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method proportion averages of cells CD4+CD25+CD127 low T in peripheral blood inclusion
- Secondary Outcome Measures
Name Time Method average relative expression of genes FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1, and TIM-3 inclusion
Trial Locations
- Locations (1)
Nephrology Unit Hôpital Nord CHU de Saint-Etienne
🇫🇷Saint-Etienne, France
Nephrology Unit Hôpital Nord CHU de Saint-Etienne🇫🇷Saint-Etienne, France