Rhythmic Risk of Type 1 Brugada Syndrome and Pulmonary Infundibulum Mapping
- Conditions
- Brugada Syndrome Type 1
- Interventions
- Device: Endocardial mapping
- Registration Number
- NCT03572881
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Brugada syndrome has been described as the association of a right bundle block with ST segment elevation on the V1 to V3 electrocardiogram in patients with a structurally normal heart. The rhythmic risk is thus difficult to evaluate in asymptomatic patients in whom the rate of events is estimated at 0.2 to 1.4% of events per year. In addition, the predictive value of ventricular pacing remains controversial; There is therefore currently no review to effectively assess rhythmic risk in patients with Brugada type I syndrome.
Investigators aimed to show a difference in pulmonary infundibulum voltage mapping in symptomatic and asymptomatic patients with Brugada type 1 syndrome with a comparable ECG.
The mapping of the pulmonary infundibulum will be performed during electrophysiological exploration. Only the catheter used differs from the usual procedure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Group 21
- Brugada Type 1 syndrome
- Age : 50-60 years old
- Asymptomatic
- Signed informed consent
Group2
- Brugada Type 1 syndrome
- Age >18 years old
- Implantable defibrillator
- Having received at least 1 appropriate shock or a sudden sudden death
- Signed informed consent
Groups 1 and 2
- Brugada Type 2 or 3 syndrome
- Contraindication to electrophysiological exploration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Asymptomatic Endocardial mapping - Symptomatic Endocardial mapping -
- Primary Outcome Measures
Name Time Method Identification of different voltage zones by endocardial mapping of the pulmonary infundibulum between asymptomatic patients with Brugada type 1 and patients with symptomatic Brugada type 1 Day 1 The voltage zone are defined with :
* measurement of unipolar and bipolar local voltage (mV)
* the scar surface
* the surface of the bordering area
* the surface of healthy tissue
* the quantification of the number of fractionated potentials and density with respect to the size of the infundibulum and the scar (if present)
* the analysis of the heterogeneity of the voltage (study of dispersion)
* analysis of propagation card velocities in sinus rhythm and ventricular pacing (mm / s)
* analysis of ventricular arrhythmia activation if positive ventricular pacing and good hemodynamic tolerance (focal / reentrant / reentrant macro).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hopital Louis Pradel
🇫🇷Bron, France