A Combined Surgical and Medical Approach in Mild Sleep Apnea
Not Applicable
- Conditions
- Sleep Apnea
- Registration Number
- NCT00497120
- Lead Sponsor
- University Hospital, Antwerp
- Brief Summary
The aim of the study is to investigate wether the adjuvant (postoperative) administration of acetazolamide can improve the surgical results after uvulopalatopharyngoplasty in patients with mild sleep apnea.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- 5 ≤ Apnea Hypopnea Index (AHI) < 20
- Socially disturbing snoring: Visual Analogue Scale (VAS)snoring > 6/10
- Based on clinical examination and polysomnography, patient is regarded eligible for uvulopalatopharyngoplasty (UPPP)
Exclusion Criteria
- Previous surgical treatment for sleep-disordered breathing.
- Periodic Limb Movement Disorder (PLMD) with arousals and other reasons possibly explaining the Excessive Daytime Sleepiness (EDS) based on Epworth Sleepiness Scale (ESS).
- Forced expiratory volume in 1 second (FEV1) < 80 % pred.
- Echocardiography: ejectionfraction < 35 % or dyastolic dysfunction grade 2 or more.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Polysomnographic parameters
- Secondary Outcome Measures
Name Time Method subjective sleepiness subjective snoring satisfaction
Trial Locations
- Locations (1)
University Hospital Antwerp
🇧🇪Edegem, Antwerp, Belgium