Evaluation of Central Sensitization Parameters Based on Extra Median Symptom Distribution in Carpal Tunnel Syndrome: A Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Pressure pain threshold
研究概览
简要总结
This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.
详细描述
Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy, typically presenting with numbness and tingling in the thumb, index, and middle fingers due to median nerve compression at the wrist. However, some patients report symptom spread beyond the median nerve distribution, involving ulnar regions of the hand, forearm, shoulder, or even scapular areas. This phenomenon, known as extra median symptom distribution, has been increasingly associated with central sensitization (CS).This study aims to compare central sensitization parameters between CTS patients with typical symptoms and those showing extra median spread. Pressure pain threshold (PPT) and Central Sensitization Inventory (CSI) scores will be used to evaluate sensitization levels. The initial hypothesis of this study was that patients with extra-median symptoms would exhibit lower PPT values and higher CSI scores, indicating greater central sensitivity. Findings may highlight the need to consider central mechanisms in CTS management and promote more personalized treatment approaches.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings
- •Being between 18 and 65 years of age
- •Being literate
- •Agreeing to participate in the study
排除标准
- •Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy
- •Being <18 and >65 years of age
- •Being illiterate
- •Refusing to participate in the study
- •Having a disease associated with neuropathic pain, such as polyneuropathy, radiculopathy, or multiple sclerosis
- •History of injection or surgery for CTS within the last 6 months
结局指标
主要结局
Pressure pain threshold
时间窗: 3 months
Pain pressure threshold (PPT) is used to measure deep muscular tissue sensitivity. Algometer is used in the measurement and low values are interpreted in favor of increased sensitivity.
Katz hand diagram
时间窗: 3 months
The Katz Hand Diagram is a self-reported symptom map used to support the diagnosis of Carpal Tunnel Syndrome (CTS). Patients are asked to mark areas on a standardized hand diagram where they experience pain, numbness, or tingling. This tool helps clinicians assess whether symptoms follow a median nerve distribution and is commonly used in both clinical and research settings due to its simplicity and diagnostic value.
次要结局
- Visual analog scale(3 months)
- Median nerve ultrasound echogenicity measurement(3 months)
- Short form-12(3 months)
- Central sensitization inventory (CSI)(3 months)
- hand grip strength(3 months)
- Median nerve conduction studies-latency measurement(3 months)
- Median nerve motor conduction studies-amplitude measurement(3 months)
- Median nerve sensory conduction studies-amplitude measurement(3 months)
- Median nerve conduction studies- conduction velocity measurement(3 months)
- Median nerve ultrasound cross-sectional area measurement(3 months)
- Self Leeds Assessment of Neuropathic Symptoms and Sign (S-LANSS)(3 months)
- Boston Carpal Tunnel Questionnaire (BCTQ)(3 months)