Embryo DNA Repair Capacity Project
Completed
- Conditions
- Infertility
- Interventions
- Genetic: double strand break
- Registration Number
- NCT03953859
- Lead Sponsor
- Reproductive Medicine Associates of New Jersey
- Brief Summary
The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA
- Detailed Description
The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
Inclusion Criteria
- gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
- IVF couples: any couples proceeding with a routine IVF cycle
Exclusion Criteria
- less than 21 years of age
- inability to provide informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Gamete donors double strand break healthy male and female game donors to undergo routine gamete donation process
- Primary Outcome Measures
Name Time Method repair of double strand break in DNA up to 12 days targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Reproductive Medicine Assoicates of New Jersey
🇺🇸Basking Ridge, New Jersey, United States