NCT03953859
Completed
Not Applicable
Investigation of Cellular DNA Repair Capacity in Human Preimplantation Embryos
ConditionsInfertility
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- Reproductive Medicine Associates of New Jersey
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- repair of double strand break in DNA
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA
Detailed Description
The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
- •IVF couples: any couples proceeding with a routine IVF cycle
Exclusion Criteria
- •less than 21 years of age
- •inability to provide informed consent
Outcomes
Primary Outcomes
repair of double strand break in DNA
Time Frame: up to 12 days
targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo
Study Sites (1)
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