3D Structural Imaging of Human Breast Tissues

National Taiwan University Hospital0 个研究点目标入组 100 人开始时间: 2024年7月1日最近更新: 2024年6月26日

适应症

试验速览

阶段: 不适用
状态: 尚未招募
发起方: National Taiwan University Hospital
入组人数: 100
主要终点: Accuracy dependency on staining dye selection

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

This project aims to develop an advanced ex vivo medical microscopic imaging technology. By developing breast tissue staining techniques, acquiring microscopic images, and performing structural reconstruction, we seek to observe the 3D structure of breast tissue. This includes examining cell distribution, mammary ducts, and blood vessel distribution, to explore the different biological characteristics between normal breast tissue and various types of cancerous tissues.

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Adults aged 18 and above.
•Patients clinically diagnosed with breast cancer.

排除标准

•Patients unable to provide consent (e.g., inability to speak, inability to communicate in Chinese, etc.).
•Patients for whom a definitive pathological diagnosis cannot be established.
•Patients suitable only for biopsy and not for surgical excision.
•Excised tissue showing severe radiation-induced changes under pathological examination.
•Tumor specimens smaller than 1 cm.
•Patients with ductal carcinoma in situ (DCIS).

结局指标

主要结局

Accuracy dependency on staining dye selection

时间窗: 3 years

Using other types of staining agents, compare the diagnostic accuracy of the results with those of traditional pathological staining agents.

次要结局

Comparison between 3D pathology vs. FFPE on breast cancer samples with a focus on image contrast(3 years)

研究者

发起方

National Taiwan University Hospital

申办方类型

Other

责任方

Sponsor

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