Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection

Phase 3

Completed

• Conditions: Bilateral Knee Osteoarthritis
• Interventions: Other: Hyaluronic acid

• Registration Number: NCT02063373
• Lead Sponsor: University of Malaya

Brief Summary

Treatment: five intro-articular Hyaluronic Acid injection

Assessment has two parts, that are as follow:

1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test

2. Gait and stair climbing assessment using Vicon motion capture system synchronized with four force plates.

For knee OA subjects, assessment was done in week one or before injection; and for healthy controls one assessment was performed.

Detailed Description

This study aimed to assess the effect of hyaluronic acid injection on Postural stability, biomechanics of gait and stair climbing in individuals with bilateral knee osteoarthritis (OA).

Participants were individuals with knee OA (control and treatment) and healthy people.

Study Timeline

• Study Start: 2012-09
• Primary Completion: 2013-10
• Status Verified: 2014-02
• Study First Submitted: 2014-02-11
• Study First Submitted QC: 2014-02-12
• Last Update Submitted: 2014-02-12
• Study First Posted: 2014-02-14
• Last Update Posted: 2014-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• Mild and moderate bilateral knee osteoarthritis
• Age between 50 and 70 years

Exclusion Criteria

• Recent Lower limb injury
• Diabetic
• Knee or hip replacement
• Knees HA injection in last 6 months
• Any neuromuscular disease such as stroke and Parkinson

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
biomechanis knee OA and HA injection	Hyaluronic acid	Weekly intra- articular Hyaluronic acid injection (20 MG/ 2 ML) into both knees for five weeks

Primary Outcome Measures

Name	Time	Method
Change in Postural stability after treatment	baseline and 6 weeks
Changes in Biomechanics of gait after treatment	baseline and 6 weeks
Changes in biomechanics of stair climbing after treatment	baseline and 6 weeks

Secondary Outcome Measures

Name	Time	Method
Change in Pain after treatment	baseline and 6 weeks
Changes in WOMAC scores after treatment	baseline and 6 weeks