NCT05670457招募中3 期
Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- assesment of improvement of symptoms as indicated by change in SAGIS scale.
研究概览
简要总结
The aim of the study is to evaluate the safety and efficacy of diosmin as adjuvant therapy in treatment of non-bleeding peptic ulcer patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •. Age 25-65 years old.
- •Patients of both gender (male and female).
- •Non-bleeding Peptic ulcer Patients (duodenal &gastric) diagnosed by endoscopy.
排除标准
- •The presence of other factors that can lead to gastric bleeding other than peptic ulcer.
- •Patients with cancerous disease
- •Breast-feeding.
- •Surgically altered stomach ( bariatric surgery),
- •Patient with liver disease.
- •Bleeding & perforated peptic ulcer.
研究组 & 干预措施
Diosmin group
Active Comparator
this group will include 22 patients who will receive anti peptic ulcer and diosmin 500 mg twice daily for 2 months.
干预措施: Diosmin (Drug)
结局指标
主要结局
assesment of improvement of symptoms as indicated by change in SAGIS scale.
时间窗: 2 months
patients will undergo clinical assessment according to SAGIS scale at baseline and 2 months
次要结局
- change in Malondialdehyde (MDA) serum levels.(2 months)
- change in Prostaglandin E2 (PGE2) serum levels.(2 months.)
- change in Endothelin-1 (ET-1) serum levels.(2 months)
- change in b-cell lymphoma 2(bcl-2) serum levels.(2 months)
研究者
Ahmed Gamal Salah Abdelfatah
principal investigator
Tanta University
研究点 (1)
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