Dual-loop Target Controlled Infusion for Coadministration of Propofol and Remifentanil Guided by Narcotrend Index in Anterior Cervical Decompression and Fusion With Internal Fixation
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- the total dose of propofol and remifentanil
- Last Updated
- 9 years ago
Overview
Brief Summary
To investigate the application of closed target-controlled infusion(TCI) of propofol and remifentanil guided by Narcotrend index in the anterior cervical decompression and fusion with internal fixation surgery.
Detailed Description
Sixty patients scheduled for anterior cervical decompression and fusion with internal fixation surgery under general anesthesia were randomly divided into two groups:closed-loop (group A,n=30) and open-loop group(group B,n=30).The procedure during induction of anesthesia was same in two groups.In group A,if Narcotrend index(NI) fall down to 46 and keep more than 30 seconds,propofol and remifentanil were intravenously infused as feedback automatically to achieve the target NI of 26-46.However,the NI in group B was controlled manually.
Investigators
bo xu
associate chief physician
Guangzhou General Hospital of Guangzhou Military Command
Eligibility Criteria
Inclusion Criteria
- •ASA Ⅰ \~ Ⅱ women undergoing Laparoscopic surgery.
- •Written informed consent from the patient or the relatives of the participating patient.
- •BMI:18.0～25 kg/m2
Exclusion Criteria
- •Mental illness can not match
- •epidural anesthesia contraindicated
- •People who have Slow-type arrhythmias
- •Chronic renal failure
- •Alcohol or drug abuse
- •Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
Outcomes
Primary Outcomes
the total dose of propofol and remifentanil
Time Frame: within three hours from the beginning to the end of the propofol and remifentanil
record the total dose of propofol and remifentanil from the beginning to the end of anesthesia