Effects of Walking Meditation on Vascular Function in Breast Cancer Patients Receiving Anthracyclines Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change from baseline in vascular reactivity
研究概览
简要总结
This study is to evaluate the effects of Walking Meditation on vascular function in breast cancer patients receiving Anthracyclines chemotherapy
详细描述
Walking Meditation program will be based on aerobic walking exercise combined with Buddhist meditation. The subjects will perform walking while listening to the sound "Budd" and "Dha" and squeeze rubber balls according to the sound in order to practice mindfulness while walking. In phase 1 (week 1-6), Walking Meditation will be conducted at initial moderate intensity (41-50% heart rate reserve) 3 sets, 10 minutes per set and rest 3 minutes between set In phase 2 (week 7-12), the training intensity will be increased to ultimate moderate intensity (51-60% heart rate reserve) 3 sets, 15 minutes per set and rest 3 minutes between set. In both phases of the training, the frequency of Walking Meditation training is three times a week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria included stage 1-2 of Breast cancer patients after an operation with or without Hormone Receptor Positive and HER2 Positive.
- •All participants will be planned to use Anthracyclines chemotherapy in next 1 month by oncologist.
- •All participants did not participate in any exercise training in the past 6 months
- •All participants are free from acute or chronic renal failure, Heart Failure, Myasthenia gravis, pregnancy and history of smoke.
排除标准
- •Participants will be excluded if they dropped out or completed less than 80% of the training schedule.
结局指标
主要结局
Change from baseline in vascular reactivity
时间窗: baseline, up to 12 weeks
Vascular reactivity or brachial artery flow-mediated dilatation (FMD) will be assessed with the ultrasound equipment (CX50, Philips, USA), using the blood occlusion technique on the forearm. The brachial artery will be illustrated above the antecubital fossa in the longitudinal plane. Brachial FMD will be measured at resting and the cuff placed around the forearm will be inflated to 50 mmHg above systolic blood pressure for 5 minutes and then deflated for 5 minutes of recovery. FMD will be calculated from the formula FMD= (D2-D1) x100/D1 when D1 is the brachial artery diameter at baseline, D2 is the maximal post-occlusion brachial artery diameter.
次要结局
- Change from baseline in Cardiac output and stroke volume(baseline, up to 12 weeks)
- Change from baseline in Maximal oxygen consumption(baseline, up to 12 weeks)
- Change from baseline in Intima-Media Thickness: IMT(baseline, up to 12 weeks)
- Change from baseline in Peripheral arterial stiffness(baseline, up to 12 weeks)
- Change from baseline in blood chemistry(baseline, up to 12 weeks)
- Change from baseline in venous blood flow(baseline, up to 12 weeks)
- Change from baseline in Body Mass Index (BMI)(baseline, up to 12 weeks)
- Change from baseline in stress indicators(baseline, up to 12 weeks)
研究者
Assoc. Prof. Dr.Daroonwan Suksom
Faculty of sports science
Chulalongkorn University