COMPARATIVE EVALUATION OF NEBULISED DEXMEDETOMIDINE AND NEBULISED MAGNESIUM SULPHATE ON ATTENUATION OF PRESSOR RESPONSE FOLLOWING LARYNGOSCOPY AND INTUBATION
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To compare the hemodynamic paramater- Heart rate, following intubation in either groups
研究概览
简要总结
This is prospective interventional double blind randomized comparative study of the effect of nebulised dexmedetomidine and magnesium sulphate on attenuation of pressor response following laryngoscopy and intubation that will be conducted under Department of Anaesthesiology, Critical Care and Perioperative medicine, Hindu Rao hospital and associated NDMC, Delhi, India. The primary outcome is the comparison of heart rate following intubation in either group within 10 mins post intubation. The secondary outcome is the comparison of other hemodynamic paramters - Systolic blood pressure, Diastolic blood pressure and mean arterial pressure in either groups within 10 mins post intubation, and to compare the occurrence and severity of postoperative sore throat ineither group ;to compare total dose of propofol required for intubation in either group and to compare postoperative sedation in either group
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient weighing between 50-80 kilograms.
- •Patients belonging to ASA Grade I and Grade II.
- •Patients undergoing elective surgeries under general anaesthesia.
排除标准
- •Patients of uncontrolled hypertension, ischemic heart disease, AV blocks, arrhythmoas, ventricular dysfunction.
- •Patients wuth hepatic and renal dysfunction.
- •Patients of anticipated difficult airway.
- •Patients allergic to the stidy drug.
- •Patient unwilling to participate in the study.
结局指标
主要结局
To compare the hemodynamic paramater- Heart rate, following intubation in either groups
时间窗: 10 mins post intubation
次要结局
- To compare other hemodynamic paramters - Systolic blood pressure, Diastolic blood pressure and mean arterial pressure in either groups.(10 mins post intubation)
- To compare the occurrence and severity of postoperative sore throat in either group.(Within one hour in recovery area)
- To compare the total dose of propofol required for intubation in either group.(2-3 mins before intubation)
- To compare postoperative sedation in either group(Within one hour in recovery room)
研究者
Dr Krishna A Sivan
Hindu Rao Hospital and North DMC medical college