Investigation of the Effects of Photobiomodulation Applications on Orthodontic Tooth Movement
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University of Gaziantep
- Enrollment
- 24
- Primary Endpoint
- Orthodontic tooth movement Change
Study Overview
Brief Summary
Increasing the speed of orthodontic treatment is an emerging clinical problem and therefore the evaluation of the effects of photobiomodulation applications and methods on orthodontic tooth movement is considered as an important factor.
When literature studies are examined, different studies have been performed on Laser and LED applications, however, the lack of a study that evaluates and compares the effectiveness of these methods in terms of clinical and biochemical parameters.
The aim of this study is to compare the effects of laser and LED applications on tooth movement speed and to investigate the effects of these applications on the gingival fluid IL-8, OPG, RANKL. Total of 24 patients with maxillary first-premolar extraction orthodontic treatment will be included in this study, and this study will consist of 3 groups, Laser, LED and placebo group. The laser will be applied on days 0,3,7,14,21,28,35, take impression of teeth and gingival fluid samples will be collected in these days.
LED group will be given 10 minutes LED for 30 days, taken impression and DOS samples will be collected on specified days. In the placebo group, the non-active pulse laser light will be kept in the teeth and the patients will not know which group in they are. Thus, the psychological dimension of the applications will be eliminated. Sampling will be done for the placebo group on the days determined.
The investigator's project proposal consists of a total of 5 work packages; Determination of patient groups in the 1st stage and obtaining consent forms, 2nd stage Photobiomodulation applications (laser, LED, placebo application), 3rd stage orthodontic measurement and evaluation of these measurements 3D environment, taking gingival fluid samples in the 4th stage and evaluating them biochemically. In the 5th stage, statistical analysis and evaluation of the results will be done.
The data will be evaluated with SPSS 21.0.In this study, it is tried to reduce the time spent in the orthodontic treatment to close the extraction area. In this way, it will contribute to economy and time saving in terms of all orthodontic treatment physicians and physicians. It will illuminate the application of LED device which is more advantageous in terms of cost and space gain in clinical practice of physicians.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 14 Years to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •adequate oral hygiene
- •Class 2 malocclusion requiring upper-premolar extraction orthodontic treatment
- •lack of congenital missing teeth in upper jaw
- •no systemic disease
Exclusion Criteria
- •patients who wish to discontinue treatment
- •patients who cannot provide oral hygiene
Arms & Interventions
Tooth Movement
Canine distalization on premolar extracted patients
Intervention: Cheese dental laser (Device)
Tooth Movement
Canine distalization on premolar extracted patients
Intervention: OrthoPulse (Device)
Tooth Movement
Canine distalization on premolar extracted patients
Intervention: Placebo (Other)
Biochemistry measurements
biochemistry analysis of IL-8, OPG, RANKL
Intervention: Cheese dental laser (Device)
Biochemistry measurements
biochemistry analysis of IL-8, OPG, RANKL
Intervention: OrthoPulse (Device)
Biochemistry measurements
biochemistry analysis of IL-8, OPG, RANKL
Intervention: Placebo (Other)
periodontal measurements
gingival and plaque index, blooding on probing, pocket depth
Intervention: Cheese dental laser (Device)
periodontal measurements
gingival and plaque index, blooding on probing, pocket depth
Intervention: OrthoPulse (Device)
periodontal measurements
gingival and plaque index, blooding on probing, pocket depth
Intervention: Placebo (Other)
Outcomes
Primary Outcomes
Orthodontic tooth movement Change
Time Frame: 1st, 3rd, 7th, 14th, 21th, 28th, 35th day
Measurement of orthodontic tooth movement (mm)
Secondary Outcomes
- OPG Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- Bleeding on Probing Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- Gingival Index Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- Plaque Index Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- RANKL Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- IL-8 Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
- Periodontal Pocket Depth Change(1st, 3rd, 7th, 14th, 21th, 28th, 35th day)
Investigators
Merve Goymen
Head of Orthodontics
University of Gaziantep