Verticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- University of Zurich
- Primary Endpoint
- Adjustment errors and trial-to-trial variability as assessed by line adjustments (subjective visual vertical (SVV)), adjustments of a rod (subjective haptic vertical (SHV)) or self-adjustments (subjective postural vertical (SPV)) after prolonged roll
Study Overview
Brief Summary
The long-term goal of this research is to advance our knowledge of how the brain combines the information of multiple sensory systems coding for spatial orientation and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). Here we evaluate different potential explanations for this bias using both vision-dependent and vision-independent paradigms of verticality perception.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ages 18-65 years
- •informed consent
Exclusion Criteria
- •Exclusion Criteria:
- •peripheral-vestibular deficit
- •disturbed consciousness
- •history of sensory deficits
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
- •pregnancy, unless excluded by a negative pregnancy test
- •known neck pain or status post neck trauma
Arms & Interventions
Single intervention arm
This is the only arm in this study, measuring verticality perception after prolonged roll-tilt over 5min.
Intervention: perception of vertical after static roll-tilt over 5min (Other)
Outcomes
Primary Outcomes
Adjustment errors and trial-to-trial variability as assessed by line adjustments (subjective visual vertical (SVV)), adjustments of a rod (subjective haptic vertical (SHV)) or self-adjustments (subjective postural vertical (SPV)) after prolonged roll
Time Frame: measurements will be obtained over periods of 5min in a single session and day
In all three paradigms (SVV, SHV and SPV) the percept of direction of gravity will be assessed. Parameters will be adjustment errors ("accuracy") and trial-to-trial variability ("precision") based on repetitive adjustments of a luminous line (SVV) or a rod (SHV) after returning to upright position after a period of 5min in static roll-tilt at 90° left-ear down or right-ear down. During the roll-tilt period subjects remain either in the dark or observe a rotating optokinetic (random dot) pattern. Individual mean values and standard deviation (SD) will be calculated for all conditions. Adjustments with the joystick (SPV) will start from 90° ear-down positions after 5min of static roll.
Secondary Outcomes
- Impact of a rotating optokinetic stimulus (velocity 60°/s) on adjustment errors as assessed by the SVV, the SHV or the SPV after 5min of static roll-tilt at +/- 90° roll.(measurements will be obtained over periods of 5min in a single session and day)