Utility of Clinical Examination in the Noninvasive Prediction of Aortic Atheroma - A Prospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atherosclerosis
- Sponsor
- Creighton University
- Enrollment
- 125
- Locations
- 1
- Primary Endpoint
- Identify clinical predictors of aortic atheromatous disease and develop risk score to identify with reasonable accuracy the presence of any aortic atheromatous disease and severe atheromatous disease (grade 4 & 5).
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Aortic atheroma has been correlated with traditional cardiac risk factors, coronary, carotid, renal and peripheral atherosclerosis, and is probably a manifestation of generalized atherosclerosis. Aortic atheroma has also been shown to be associated with atrial fibrillation, aortic valve sclerosis, and other calcification of the fibrous skeleton of the heart. None of the previous studies have looked at the noninvasive prediction of aortic atheroma using the history and physical signs of cardiovascular disease. This would be a time and cost-effective bedside diagnostic tool that would be useful prior to cardiac surgery, cardiac catheterization, and workup of ischemic stroke patients, especially when transesophageal echocardiogram (TEE) is being considered for diagnosis but cannot be obtained due to previously mentioned reasons. Although physical examination of peripheral vascular disease is non-specific, a combination of physical examination signs increases the probability of generalized atherosclerosis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All consecutive patients who are referred for transesophageal echocardiography (TEE) since the primary endpoint is diagnosis of aortic atheroma on TEE
Exclusion Criteria
- •No exclusion after consent for TEE is obtained. Decision not to perform TEE at the discretion of treating physician
Outcomes
Primary Outcomes
Identify clinical predictors of aortic atheromatous disease and develop risk score to identify with reasonable accuracy the presence of any aortic atheromatous disease and severe atheromatous disease (grade 4 & 5).
Time Frame: 6 month. 1 year and 2 year
Secondary Outcomes
- Demonstrate the incremental value of physical exam signs to the history.(6 month, 1 and 2 years)
- Follow-up on embolic events - transient ischemic attack (TIA), stroke and mortality and effect of medications(6 months, 1 and 2 years)