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临床试验/NCT00590616
NCT00590616已完成不适用

Utility of Clinical Examination in the Noninvasive Prediction of Aortic Atheroma - A Prospective Study

Creighton University1 个研究点 分布在 1 个国家目标入组 125 人开始时间: 2005年2月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
125
试验地点
1
主要终点
Identify clinical predictors of aortic atheromatous disease and develop risk score to identify with reasonable accuracy the presence of any aortic atheromatous disease and severe atheromatous disease (grade 4 & 5).

研究概览

简要总结

Aortic atheroma has been correlated with traditional cardiac risk factors, coronary, carotid, renal and peripheral atherosclerosis, and is probably a manifestation of generalized atherosclerosis. Aortic atheroma has also been shown to be associated with atrial fibrillation, aortic valve sclerosis, and other calcification of the fibrous skeleton of the heart. None of the previous studies have looked at the noninvasive prediction of aortic atheroma using the history and physical signs of cardiovascular disease. This would be a time and cost-effective bedside diagnostic tool that would be useful prior to cardiac surgery, cardiac catheterization, and workup of ischemic stroke patients, especially when transesophageal echocardiogram (TEE) is being considered for diagnosis but cannot be obtained due to previously mentioned reasons. Although physical examination of peripheral vascular disease is non-specific, a combination of physical examination signs increases the probability of generalized atherosclerosis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
19 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All consecutive patients who are referred for transesophageal echocardiography (TEE) since the primary endpoint is diagnosis of aortic atheroma on TEE

排除标准

  • No exclusion after consent for TEE is obtained. Decision not to perform TEE at the discretion of treating physician

结局指标

主要结局

Identify clinical predictors of aortic atheromatous disease and develop risk score to identify with reasonable accuracy the presence of any aortic atheromatous disease and severe atheromatous disease (grade 4 & 5).

时间窗: 6 month. 1 year and 2 year

次要结局

  • Demonstrate the incremental value of physical exam signs to the history.(6 month, 1 and 2 years)
  • Follow-up on embolic events - transient ischemic attack (TIA), stroke and mortality and effect of medications(6 months, 1 and 2 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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