NL-OMON45644
Completed
Not Applicable
Pharmacodynamic interactions between remifentanil and dexmedetomidine (PIRAD) - PD interaction of REMI and DMED
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 30
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- American Society of Anesthesiologists (ASA) Physical Status 1;\- No medical history of significance;\- No chronic use of medication, drugs, tobacco or more than 20 gr alcohol daily (oral contraceptives excluded). ;\- Concerning the cognitive function: Volunteers are considered to have sufficient cognitive reserve if they are able to read and comprehend the patient information form, if they can adequately answer the anamnestic questions during the screening process and if they are allowed to provide legitimate written informed consent. ;\- No selection will be made regarding ethnic background;\- No exclusion criterium is present
Exclusion Criteria
- •\- Known intolerance to dexmedetomidine or remifentanil;\- Volunteer refusal ;\- Age \< 18 years or \>70 years ;\- Pregnancy, or currently nursing;\- Hairstyle with dreadlocks (EEG\-monitoring will not be possible);\- Body mass index (BMI) \<18 or \>30 kg/m2\. ;\- Neurological disorder (epilepsy, the presence of a brain tumor, a history of brain surgery, hydrocephalic disorders, depression needing treatment with anti\-depressive drugs, a history of brain trauma, a subarachnoidal bleeding, TIA or cerebral infarct, psychosis or dementia , schizophrenia, alcohol or drug abuse). ;\- Diseases involving the cardiovascular system (hypertension, coronary artery disease, prior acute myocardial infarction, any valvular and/or myocardial disease involving decrease in ejection fraction, arrhythmias, which are either symptomatic or require continuous medication/pacemaker/automatic internal cardioverter defibrillator)
- •\- Recent use of psycho\-active medication (benzodiazepines, anti\-epileptic drugs, parkinson medication, anti\-depressant drugs, opioids) or more than 20 g of alcohol daily.
- •\- Bilateral non\-patent a. ulnaris
- •\- Any other condition relevant to the study
Outcomes
Primary Outcomes
Not specified
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