The Critical Threshold of Pulse Oximetry Plethysmographic Waveform Parameters in High Quality CPR

• Conditions: Cardiopulmonary Resuscitation

• Registration Number: NCT03754946
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

The purpose of this study is to analyze the relationship of the area under the curve (AUC) and/or the amplitude (Amp) of pulse oximetry plethysmographic waveform (POP) with partial pressure of end-tidal carbon dioxide (PETCO2) which could be used to reflect its quality in cardiopulmonary resuscitation (CPR), and then to determine the critical threshold of POP parameters in high quality CPR.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-01
• Primary Completion: 2018-06-30
• Status Verified: 2018-11
• Study First Submitted: 2018-11-15
• Study First Submitted QC: 2018-11-26
• Last Update Submitted: 2018-11-26
• Study First Posted: 2018-11-27
• Last Update Posted: 2018-11-27
• Study Completion: 2018-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Cardiac arrested
• The time from cardiac arrest to receiving basic life support is less than 10 minutes
• Get advanced life support (endotracheal intubation and PETCO2 monitoring)

Exclusion Criteria

• Defuse CPR
• chronic obstructive pulmonary disease (COPD) with type II respiratory failure
• Terminal malignant tumors or terminal stage of other diseases
• Rib fracture
• Cardiac arrest caused by hemorrhagic shock pulmonary embolism and cardiac tamponade
• Sever anemia(HGB<7g/dl)
• Untreated tension pneumothorax
• Tinea unguium, dyeing Fingernails and other factors affect the monitor of Pulse Oximetry Plethysmographic Waveform such vasculitis and Raynaud's phenomenon

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the cut-off value of POP parameters in High Quality CPR	one year	Describe the the cut-off value of POP parameters in High Quality CPR. Receiver operating curve analysis was performed to evaluate the accuracy in predicting return of spontaneous circulation (ROSC).
Compare different predictors	one year	Area under curve (AUC) between potential predictors was compared by using a nonparametric test, and the optimal cutoff point was determined by estimating the Youden's index.

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, China