The efficacy of prophylactic treatment with oral acetaminophen for closure of patent ductus arteriosus in preterm infants

Not Applicable

• Conditions: patent ductus arteriosus.; Congenital malformations of great arteries

• Registration Number: IRCT2014090519050N1
• Lead Sponsor: Vice Chancellor for research of Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Premature neonates born at or before 32 weeks of gestation with birth weight less than or equal to 1500 grams admitted in neonatal intensive care unit of Vali-e-Asr Hospital in 2012; parental consent for participating in this study. Exclusion criteria: Newborns with congenital heart defects that patency of ductus arteriosus is vital for them such as pulmonary atresia; congenital major anomalies or chromosomal abnormalities; maternal consumption of none steroidal anti-inflammatory drugs during pregnancy; newborns with hydrops fetalis or persistent pulmonary hypertension of the newborn; apgar score less than 5 at fifth minute after birth; appearance of patent of dutus arteriosus symptoms and requirement for treatment with Ibuprofen at any time; having vomiting or hematemesis during first 3 days after birth; neonates with glucose-6-phosphate dehydrogenase deficiency based on blood exam at beginning of neonatal admission

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eft Atrial to Aortic Ratio. Timepoint: 4-5 day of life. Method of measurement: Echocardiography.;Internal Ductal Diameter. Timepoint: 4-5 day of life. Method of measurement: Echocardiography.