Effect of Psyllium seed on the gastric reflux in patients with constipatio
Phase 3
- Conditions
- Gastro-esophageal reflux disease.Gastro-esophageal reflux disease with esophagitis
- Registration Number
- IRCT2015040315122N2
- Lead Sponsor
- Vice chancellor for research, Mashad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 132
Inclusion Criteria
Symptomatic patients with minimum three years history of gastroesophageal reflux disease and functional constipation whose esophagitis in upper endoscopy will be confirmed.
Exclusion criteria: History of or current gastrointestinal cancer; Hiatal hernia; Irritable bowel syndrome; Endocrine diseases (e.g., hypothyroidism); Drug-induced constipation; Psychological disorders; Cardiovascular diseases; Liver diseases; Renal diseases; Opiums abuse
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment reflux disease remission with constipation improvement. Timepoint: First day, 7th day, 14th day, 21th day, 28th day, 35th day,42th day, 49th day and 56th day after intervention. Method of measurement: History of heart burn and regurgitation(clinical symptoms of GERD) was taken. Then the visual scale was used for evaluation.
- Secondary Outcome Measures
Name Time Method