Effect of Lorcaserin on Cannabis Withdrawal and Self-administration
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Cannabis Self-administration
研究概览
简要总结
In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.
详细描述
In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have developed a laboratory model to investigate the effects of potential treatment medications on cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non treatment-seeking cannabis smokers. In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Current cannabis use
- •Able to give informed consent and perform study procedures
- •Women practicing an effective form of birth control
- •English speaking
排除标准
- •Presence of any clinically significant medical diagnoses
- •History of heart disease and cardiac risk factors, severe chronic obstructive pulmonary disease, uncontrolled hypertension, or diabetes
- •Current parole or probation
- •Certain psychiatric diagnoses
- •Current pregnancy or lactation
研究组 & 干预措施
Lorcaserin + Marijuana
干预措施: Lorcaserin (Drug)
Lorcaserin + Marijuana
干预措施: Marijuana (Drug)
Placebo + Marijuana
干预措施: Placebo (Drug)
Placebo + Marijuana
干预措施: Marijuana (Drug)
结局指标
主要结局
Cannabis Self-administration
时间窗: 14 days
Number of cannabis puffs participant chooses to smoke.
次要结局
未报告次要终点
研究者
Margaret Haney
Professor of Neurobiology (in Psychiatry) at CUMC
New York State Psychiatric Institute