Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

Phase 1

Completed

• Conditions: Cannabis Use
• Interventions: Drug: Lorcaserin; Drug: Placebo; Drug: Marijuana

• Registration Number: NCT03253926
• Lead Sponsor: New York State Psychiatric Institute

Brief Summary

In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Detailed Description

In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have developed a laboratory model to investigate the effects of potential treatment medications on cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non treatment-seeking cannabis smokers. In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Study Timeline

• Study First Submitted: 2017-08-14
• Study First Submitted QC: 2017-08-17
• Study First Posted: 2017-08-18
• Study Start: 2017-09-05
• Primary Completion: 2021-05-31
• Study Completion: 2021-12-31
• Results First Submitted: 2022-05-31
• Status Verified: 2022-07
• Results First Submitted QC: 2022-07-25
• Last Update Submitted: 2022-07-25
• Results First Posted: 2022-07-26
• Last Update Posted: 2022-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Current cannabis use
• Able to give informed consent and perform study procedures
• Women practicing an effective form of birth control
• English speaking

Exclusion Criteria

• Presence of any clinically significant medical diagnoses
• History of heart disease and cardiac risk factors, severe chronic obstructive pulmonary disease, uncontrolled hypertension, or diabetes
• Current parole or probation
• Certain psychiatric diagnoses
• Current pregnancy or lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Lorcaserin + Marijuana	Lorcaserin	-
Lorcaserin + Marijuana	Marijuana	-
Placebo + Marijuana	Placebo	-
Placebo + Marijuana	Marijuana	-

Primary Outcome Measures

Name	Time	Method
Cannabis Self-administration	14 days	Number of cannabis puffs participant chooses to smoke.

Trial Locations

Locations (1)

New York State Psychiatric Institute; 🇺🇸 New York, New York, United States