International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry

Recruiting

• Conditions: Gaucher Disease; Cerebroside Lipidosis Syndrome; Glucocerebrosidase Deficiency Disease; Glucosylceramide Beta-Glucosidase Deficiency Disease

• Registration Number: NCT00358943
• Lead Sponsor: Genzyme, a Sanofi Company

Brief Summary

The ICGG Gaucher Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Gaucher disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician.

The objectives of the Registry are:

* To enhance understanding of the variability, progression, identification, and natural history of Gaucher disease, with the ultimate goal of better guiding and assessing therapeutic intervention.

* To assist the Gaucher medical community with the development of recommendations for monitoring patients, and to provide reports on patient outcomes, to optimize patient care.

* To characterize the Gaucher disease population.

* To evaluate the long-term effectiveness of imiglucerase and of eliglustat.

Gaucher Pregnancy Sub-registry: The primary objective of this Sub-registry is to track pregnancy outcomes, including complications and infant growth, in all women with Gaucher disease during pregnancy, regardless of whether they receive disease-specific therapy. No experimental intervention is given; thus a patient will undergo clinical assessments and receive standard of care treatment as determined by the patient's physician.If a patient consents to this Sub-registry, information about the patient's medical and obstetric history, pregnancy, and birth will be collected, and, if a patient consents to data collection for her infant, data on infant growth through month 36 postpartum will be collected.

Detailed Description

Not available

Study Timeline

• Study Start: 1991-04-01
• Study First Submitted: 2006-07-12
• Study First Submitted QC: 2006-07-31
• Study First Posted: 2006-08-01
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-19
• Last Update Posted: 2024-11-20
• Primary Completion: 2034-01-31
• Study Completion: 2034-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 12000

Inclusion Criteria

ICGG Gaucher Registry

• All patients with a confirmed diagnosis of Gaucher disease are eligible for inclusion in the Registry. Confirmed diagnosis is defined as a documented β-glucocerebrosidase deficiency and/or mutation in the β-glucocerebrosidase gene.
• For all patients, appropriate patient authorization will be obtained.

Gaucher Pregnancy Sub-registry:

• be enrolled in the ICGG Gaucher Registry.
• be pregnant, or have been pregnant with appropriate medical documentation available.
• provide a signed informed consent and authorization form(s) to participate in the Sub-Registry prior to any Sub-Registry-related data collection being performed.

Exclusion Criteria

• No exclusion criteria for participation in the ICGG Gaucher Registry and Sub-registry.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ICGG Gaucher Registry: To provide the Gaucher medical community with recommendations for monitoring patients and to provide reports on patient outcomes to help optimize patient care	42 years
Gaucher Pregnancy Sub-registry: To track pregnancy outcomes, including complications and infant growth, in all women with Gaucher disease during pregnancy, regardless of whether they receive disease-specific therapy, such as ERT with imiglucerase	42 years

Trial Locations

Locations (315)

Phoenix Children's Hospital- Site Number : 840003; 🇺🇸 Phoenix, Arizona, United States

University of Arizona- Site Number : 840015; 🇺🇸 Tucson, Arizona, United States

Arkansas Childrens Hospital- Site Number : 840109; 🇺🇸 Little Rock, Arkansas, United States

University of Arkansas for Medical Sciences- Site Number : 840113; 🇺🇸 Little Rock, Arkansas, United States

Tower Hematology/Oncology Medical Group- Site Number : 840056; 🇺🇸 Beverly Hills, California, United States

University of California at Irvine- Site Number : 840036; 🇺🇸 Irvine, California, United States

Southern California Permanente Medical Group- Site Number : 840108; 🇺🇸 Los Angeles, California, United States

USC Health Sciences Center Dept of Genetics- Site Number : 840082; 🇺🇸 Los Angeles, California, United States

Children's Hospital of Orange County- Site Number : 840074; 🇺🇸 Orange, California, United States

Stanford Unviersity MC Dept of Genetics- Site Number : 840022; 🇺🇸 Palo Alto, California, United States

UC Davis MIND Institute- Site Number : 840010; 🇺🇸 Sacramento, California, United States

Kaiser Permanente Hospital- Site Number : 840042; 🇺🇸 Sacramento, California, United States

Loma Linda University Children's Hospital- Site Number : 840117; 🇺🇸 San Bernardino, California, United States

University of California at San Diego- Site Number : 840007; 🇺🇸 San Diego, California, United States

University of California at San Francisco- Site Number : 840051; 🇺🇸 San Francisco, California, United States

Yale - Site Number : 840047; 🇺🇸 New Haven, Connecticut, United States

Children's National Medical Center- Site Number : 840067; 🇺🇸 Washington, District of Columbia, United States

University Hematology Oncology- Site Number : 840075; 🇺🇸 Coral Springs, Florida, United States

University of Florida Pediatrics Genetics- Site Number : 840121; 🇺🇸 Jacksonville, Florida, United States

The Atwal Clinic- Site Number : 840112; 🇺🇸 Jacksonville, Florida, United States

University Of Miami SOM- Site Number : 840006; 🇺🇸 Miami, Florida, United States

University of Florida-Genetics- Site Number : 840096; 🇺🇸 Tampa, Florida, United States

Pediatric Endocrine Associates- Site Number : 840017; 🇺🇸 Tampa, Florida, United States

Emory University School of Medicine- Human Genetics- Site Number : 840060; 🇺🇸 Decatur, Georgia, United States

University of Colorado at Denver Genetics- Site Number : 840068; 🇺🇸 Aurora, Illinois, United States

Ann and Robert Lurie Children's Hospital- Site Number : 840011; 🇺🇸 Chicago, Illinois, United States

Ann and Robert Lurie Children's Hospital- Site Number : 840013; 🇺🇸 Chicago, Illinois, United States

Rush University Medical Center Genetics- Site Number : 840079; 🇺🇸 Chicago, Illinois, United States

Indianapolis University School of Medicine- Site Number : 840027; 🇺🇸 Indianapolis, Indiana, United States

University of Iowa- Site Number : 840032; 🇺🇸 Iowa City, Iowa, United States

University of Louisville- Genetics- Site Number : 840030; 🇺🇸 Louisville, Kentucky, United States

Tulane University Medical Center- Site Number : 840001; 🇺🇸 New Orleans, Louisiana, United States

Ochsner Medical Center - Site Number : 840120; 🇺🇸 New Orleans, Louisiana, United States

Maine Medical Center Pediatrics- Site Number : 840064; 🇺🇸 Portland, Maine, United States

John Hopkins- Site Number : 840044; 🇺🇸 Baltimore, Maryland, United States

Massachusetts General Hospital-Genetics- Site Number : 840062; 🇺🇸 Boston, Massachusetts, United States

Boston Children's Hospital- Site Number : 840092; 🇺🇸 Boston, Massachusetts, United States

University of Michigan Pediatrics- Site Number : 840107; 🇺🇸 Ann Arbor, Michigan, United States

Children's Hospital of Michigan- Site Number : 840066; 🇺🇸 Detroit, Michigan, United States

Infusion Associates- Site Number : 840050; 🇺🇸 Grand Rapids, Michigan, United States

Children's Health Care- Site Number : 840114; 🇺🇸 Minneapolis, Minnesota, United States

Children's Hospital and Clinics of Minnesota- Site Number : 840046; 🇺🇸 Minneapolis, Minnesota, United States

University of Minnesota Medical Center Pediatrics- Site Number : 840076; 🇺🇸 Minneapolis, Minnesota, United States

University of Missouri Health System Department of Genetics- Site Number : 840031; 🇺🇸 Columibia, Missouri, United States

Children's Mercy Hospital- Pediatrics- Site Number : 840063; 🇺🇸 Kansas City, Missouri, United States

Washington University of St. Louis- Site Number : 840100; 🇺🇸 Saint Louis, Missouri, United States

University of Nebraska Medical Center- Pediatrics- Site Number : 840084; 🇺🇸 Omaha, Nebraska, United States

Children's Specialty Center of Nevada- Site Number : 840008; 🇺🇸 Las Vegas, Nevada, United States

Cooper Health Center- Site Number : 840098; 🇺🇸 Camden, New Jersey, United States

Joseph M. Sanzari Children's Hospital- Site Number : 840101; 🇺🇸 Hackensack, New Jersey, United States

Atlantic Health System- Site Number : 840099; 🇺🇸 Morristown, New Jersey, United States

St. Peter's University Hospital- Site Number : 840016; 🇺🇸 New Brunswick, New Jersey, United States

St. Joseph's Children's Hospital- Site Number : 840057; 🇺🇸 Paterson, New Jersey, United States

Northwell Health- Site Number : 840102; 🇺🇸 Manhasset, New York, United States

New York University School Of Medicine- Site Number : 840040; 🇺🇸 New York, New York, United States

Metropolitan Hospital Center- Site Number : 840110; 🇺🇸 New York, New York, United States

Mt. Sinai School of Medicine- Site Number : 840005; 🇺🇸 New York, New York, United States

University of Rochester Medical Center SOM- Site Number : 840105; 🇺🇸 Rochester, New York, United States

State University of New York- Site Number : 840052; 🇺🇸 Syracuse, New York, United States

New York Medical College- Site Number : 840039; 🇺🇸 Valhalla, New York, United States

Carolinas Medical Center Hospital- Site Number : 840065; 🇺🇸 Charlotte, North Carolina, United States

Duke University Medical Center Genetics Dept- Site Number : 840037; 🇺🇸 Durham, North Carolina, United States

UHCMC- Site Number : 840119; 🇺🇸 Cleveland, Ohio, United States

Cleveland Clinic Foundation Pediatrics- Site Number : 840048; 🇺🇸 Cleveland, Ohio, United States

Nationwide Children's Hospital- Site Number : 840091; 🇺🇸 Columbus, Ohio, United States

LSD Data Registry Site LLC- Site Number : 840094; 🇺🇸 Dublin, Ohio, United States

Oregon Health and Science University- Site Number : 840080; 🇺🇸 Portland, Oregon, United States

Children's Hospital of Philadelphia HUP Medical Genetics- Site Number : 840089; 🇺🇸 Philadelphia, Pennsylvania, United States

Children's Hospital of Philadelphia- Site Number : 840034; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pittsburgh- Site Number : 840023; 🇺🇸 Pittsburgh, Pennsylvania, United States

Rhode Island Hospital Genetics- Site Number : 840053; 🇺🇸 Providence, Rhode Island, United States

Greenwood Genetcs- Site Number : 840055; 🇺🇸 Greenville, South Carolina, United States

Vanderbilt University Hospital-Pediatrics- Site Number : 840049; 🇺🇸 Nashville, Tennessee, United States

Baylor Research Center- Site Number : 840058; 🇺🇸 Dallas, Texas, United States

Cook Children's Health Care System- Site Number : 840024; 🇺🇸 Fort Worth, Texas, United States

University of Utah Department of Medical Genetics- Site Number : 840043; 🇺🇸 Salt Lake City, Utah, United States

University of Virginia School of Medicine-Pediatrics- Site Number : 840078; 🇺🇸 Charlottesville, Virginia, United States

O&O Alpan, LLC- Site Number : 840025; 🇺🇸 Fairfax, Virginia, United States

Children's Hospital of the Kings Daughters- Site Number : 840072; 🇺🇸 Norfolk, Virginia, United States

Seattle Children's Hospital- Site Number : 840028; 🇺🇸 Seattle, Washington, United States

University Of Washington Medical Center- Site Number : 840059; 🇺🇸 Seattle, Washington, United States

Multicare Health System ¿ Mary Bridge Childrens Hospital- Site Number : 840115; 🇺🇸 Tacoma, Washington, United States

Children's Hospital of Wisconsin-Pediatrics- Site Number : 840054; 🇺🇸 Milwaukee, Wisconsin, United States

Investigational Site Number : 151431; 🇦🇺 Sydney, New South Wales, Australia

Investigational Site Number : 151156; 🇧🇪 Bruges, Belgium

Hospital das Clínicas da Universidade Federal do Paraná - HCUFPR- Site Number : 076010; 🇧🇷 Curitiba, Paraná, Brazil

Hospital de Clinicas de Porto Alegre- Site Number : 076007; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Hospital e Maternidade Celso Pierro - PUC-Campinas- Site Number : 076012; 🇧🇷 Campinas, São Paulo, Brazil

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 076001; 🇧🇷 Ribeirão Preto, São Paulo, Brazil

Hospital das ClÃ-nicas da Faculdade de Medicina da USP- Site Number : 076008; 🇧🇷 SãO Paulo, São Paulo, Brazil

Faculdade De Medicina - Unicamp- Site Number : 076005; 🇧🇷 Campinas, Brazil

HEMORIO- Site Number : 076006; 🇧🇷 Rio de Janeiro, Brazil

Instituto de Genética e Erros Inatos do Metabolismo - IGEIM- Site Number : 076002; 🇧🇷 São Paulo, Brazil

Investigational Site Number : 124005; 🇨🇦 Kingston, Ontario, Canada

Investigational Site Number : 151787; 🇨🇳 Beijing, China

Investigational Site Number : 156003; 🇨🇳 Beijing, China

Investigational Site Number : 152357; 🇨🇳 Guangzhou, China

Investigational Site Number : 152358; 🇨🇳 Hangzhou, China

Investigational Site Number : 152359; 🇨🇳 Hangzhou, China

Investigational Site Number : 152356; 🇨🇳 Shanghai, China

Investigational Site Number : 150899; 🇨🇳 Shanghai, China

Investigational Site Number : 250011; 🇫🇷 Marseille, France

Investigational Site Number : 250007; 🇫🇷 Paris, France

Investigational Site Number : 154208; 🇰🇷 Yangsan, Gyeongsangnam-do, Korea, Republic of

Investigational Site Number : 151171; 🇳🇱 Amsterdam, Netherlands

Investigational Site Number : 153251; 🇪🇸 Madrid, Spain

Site Number : 840026; 🇺🇸 New York, New York, United States

Investigational Site Number : 150661; 🇦🇷 Caba, Buenos Aires, Argentina

Investigational Site Number : 032003; 🇦🇷 La Plata, Buenos Aires, Argentina

Investigational Site Number : 151085; 🇦🇷 Sarandi, Buenos Aires, Argentina

Investigational Site Number : 032012; 🇦🇷 Buenos Aires, Argentina

Investigational Site Number : 154176; 🇦🇷 Corrientes, Argentina

Investigational Site Number : 032011; 🇦🇷 Córdoba, Argentina

Investigational Site Number : 151069; 🇦🇺 Westmead, New South Wales, Australia

Investigational Site Number : 151010; 🇦🇺 Brisbane, Queensland, Australia

Investigational Site Number : 151491; 🇦🇺 Douglas, Queensland, Australia

Investigational Site Number : 151002; 🇦🇺 Adelaide, South Australia, Australia

Investigational Site Number : 151725; 🇦🇺 Hobart, Tasmania, Australia

Investigational Site Number : 151011; 🇦🇺 Clayton, Victoria, Australia

Investigational Site Number : 151008; 🇦🇺 Parkville, Victoria, Australia

Investigational Site Number : 151015; 🇦🇺 Murdoch, Western Australia, Australia

Investigational Site Number : 150722; 🇧🇪 Antwerp, Belgium

Investigational Site Number : 150944; 🇧🇪 Brussels, Belgium

Investigational Site Number : 152345; 🇧🇪 Brussels, Belgium

Investigational Site Number : 150517; 🇧🇪 Brussels, Belgium

Investigational Site Number : 151796; 🇧🇪 Bruxelles, Belgium

Investigational Site Number : 154285; 🇧🇪 Edegem, Belgium

Investigational Site Number : 151134; 🇧🇪 Gent, Belgium

Investigational Site Number : 151668; 🇧🇪 Leuven, Belgium

Investigational Site Number : 100001; 🇧🇬 Sofia, Bulgaria

Investigational Site Number : 151164; 🇧🇬 Sofia, Bulgaria

Investigational Site Number : 124014; 🇨🇦 Calgary, Alberta, Canada

Investigational Site Number : 124002; 🇨🇦 Edmonton, Alberta, Canada

Investigational Site Number : 124010; 🇨🇦 Vancouver, British Columbia, Canada

Investigational Site Number : 124011; 🇨🇦 Vancouver, British Columbia, Canada

Investigational Site Number : 124019; 🇨🇦 Winnipeg, Manitoba, Canada

Investigational Site Number : 124022; 🇨🇦 Moncton, New Brunswick, Canada

Investigational Site Number : 124024; 🇨🇦 Kingston, Ontario, Canada

Investigational Site Number : 124021; 🇨🇦 London, Ontario, Canada

Investigational Site Number : 124006; 🇨🇦 Toronto, Ontario, Canada

Investigational Site Number : 124013; 🇨🇦 Toronto, Ontario, Canada

Investigational Site Number : 124001; 🇨🇦 Sherbrooke, Quebec, Canada

Investigational Site Number : 1910001; 🇭🇷 Zagreb, Croatia

Investigational Site Number : 1910002; 🇭🇷 Zagreb, Croatia

Investigational Site Number : 1910003; 🇭🇷 Zagreb, Croatia

Investigational Site Number : 150809; 🇨🇿 Praha 2, Czechia

Investigational Site Number : 151229; 🇩🇰 København Ø, Denmark

Investigational Site Number : 2140001; 🇩🇴 Santo Domingo, Dominican Republic

Investigational Site Number : 5748; 🇪🇬 Alexandria, Egypt

Investigational Site Number : 9889; 🇪🇬 Ash Sharqia, Egypt

Investigational Site Number : 9888; 🇪🇬 Assuit, Egypt

Investigational Site Number : 9829; 🇪🇬 Cairo, Egypt

Investigational Site Number : 8345; 🇪🇬 Cairo, Egypt

Investigational Site Number : 9830; 🇪🇬 Cairo, Egypt

Investigational Site Number : 250015; 🇫🇷 Angers, France

Investigational Site Number : 250004; 🇫🇷 Besançon, France

Investigational Site Number : 250008; 🇫🇷 Bordeaux, France

Investigational Site Number : 250005; 🇫🇷 Brest, France

Investigational Site Number : 250014; 🇫🇷 BRON Cedex, France

Investigational Site Number : 250002; 🇫🇷 Caen, France

Investigational Site Number : 250001; 🇫🇷 CLICHY Cedex, France

Investigational Site Number : 250003; 🇫🇷 Garches, France

Investigational Site Number : 250009; 🇫🇷 LYON Cedex 03, France

Investigational Site Number : 2500013; 🇫🇷 Montpellier, France

Investigational Site Number : 250006; 🇫🇷 NANTES Cedex 1, France

Investigational Site Number : 250010; 🇫🇷 Paris, France

Investigational Site Number : 250012; 🇫🇷 Rennes, France

Investigational Site Number : 250018; 🇫🇷 Strasbourg, France

Investigational Site Number : 250017; 🇫🇷 Toulouse, France

Investigational Site Number : 250016; 🇫🇷 TOURS Cedex 9, France

Investigational Site Number : 151686; 🇩🇪 Berlin, Germany

Investigational Site Number : 150783; 🇩🇪 Düsseldorf, Germany

Investigational Site Number : 154150; 🇩🇪 Gießen, Germany

Investigational Site Number : 151369; 🇩🇪 Hamburg, Germany

Investigational Site Number : 151368; 🇩🇪 Hamburg, Germany

Investigational Site Number : 150031; 🇩🇪 Mainz, Germany

Investigational Site Number : 150432; 🇩🇪 Oberhausen, Germany

Investigational Site Number : 300002; 🇬🇷 Athens, Greece

Investigational Site Number : 300004; 🇬🇷 Athens, Greece

Investigational Site Number : 300003; 🇬🇷 Patras, Greece

Investigational Site Number : 300001; 🇬🇷 Thessaloniki, Greece

Investigational Site Number : 344001; 🇭🇰 Kowloon, Hong Kong

Investigational Site Number : 3480006; 🇭🇺 Budapest, Hungary

Investigational Site Number : 3480003; 🇭🇺 Létavértes, Hungary

Investigational Site Number : 3480007; 🇭🇺 Nyíregyháza, Hungary

Investigational Site Number : 3480008; 🇭🇺 Székesfehérvár, Hungary

Investigational Site Number : 356003; 🇮🇳 Ahmedabad, India

Investigational Site Number : 356004; 🇮🇳 Jaipur, India

Investigational Site Number : 356001; 🇮🇳 Kolkata, India

Investigational Site Number : 356005; 🇮🇳 Mumbai, India

Investigational Site Number : 3560006; 🇮🇳 Secunderabad, India

Investigational Site Number : 356002; 🇮🇳 Vellore, India

Investigational Site Number : 360001; 🇮🇩 Jakarta, Indonesia

Investigational Site Number : 3760003; 🇮🇱 Haifa, Israel

Investigational Site Number : 3760001; 🇮🇱 Jerusalem, Israel

Investigational Site Number : 3760002; 🇮🇱 Petach-Tikva, Israel

Investigational Site Number : 380008; 🇮🇹 Catania, Italy

Investigational Site Number : 380009; 🇮🇹 Firenze, Italy

Investigational Site Number : 380006; 🇮🇹 Genova, Italy

Investigational Site Number : 380004; 🇮🇹 Milano, Italy

Investigational Site Number : 380005; 🇮🇹 Modena, Italy

Investigational Site Number : 380002; 🇮🇹 Monza (MB), Italy

Investigational Site Number : 380011; 🇮🇹 Monza, Italy

Investigational Site Number : 380010; 🇮🇹 Napoli, Italy

Investigational Site Number : 380003; 🇮🇹 Padova, Italy

Investigational Site Number : 380007; 🇮🇹 Rome, Italy

Investigational Site Number : 380001; 🇮🇹 Udine, Italy

Investigational Site Number : 153205; 🇯🇵 Abeno-ku, Osaka, Japan

Investigational Site Number : 153203; 🇯🇵 Yonago-shi, Tottori, Japan

Investigational Site Number : 153217; 🇯🇵 Chiba, Japan

Investigational Site Number : 153204; 🇯🇵 Tokyo, Japan

Investigational Site Number : 4000001; 🇯🇴 Amman, Jordan

Investigational Site Number : 151149; 🇰🇷 Seoul, Gyeonggi-do, Korea, Republic of

Investigational Site Number : 153178; 🇰🇷 Yangsan-si, Gyeongsangnam-do, Korea, Republic of

Investigational Site Number : 154148; 🇰🇷 Yangsan, Gyeongsangnam-do, Korea, Republic of

Investigational Site Number : 153191; 🇰🇷 Daejeon, Korea, Republic of

Investigational Site Number : 153225; 🇰🇷 Jeonnam, Korea, Republic of

Investigational Site Number : 153180; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153196; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153192; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153212; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153222; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 154225; 🇰🇼 Kuwait, Kuwait

Investigational Site Number : 4220002; 🇱🇧 Beirut, Lebanon

Investigational Site Number : 4220004; 🇱🇧 Beirut, Lebanon

Investigational Site Number : 422001; 🇱🇧 Beirut, Lebanon

Investigational Site Number : 422006; 🇱🇧 Douris, Lebanon

Investigational Site Number : 154237; 🇱🇹 Vilnius, Lithuania

Investigational Site Number : 458001; 🇲🇾 Jalan Pahang, Malaysia

Investigational Site Number : 458002; 🇲🇾 Kuala Lumpur, Malaysia

Investigational Site Number : 150149; 🇳🇱 Amsterdam, Netherlands

Investigational Site Number : 154264; 🇵🇰 Karachi, Pakistan

Investigational Site Number : 154266; 🇵🇰 Lahore, Pakistan

Investigational Site Number : 604001; 🇵🇪 Arequipa, Peru

Investigational Site Number : 604002; 🇵🇪 Callao, Peru

Investigational Site Number : 608001; 🇵🇭 Manila, Philippines

Investigational Site Number : 150575; 🇵🇱 Warszawa, Poland

Investigational Site Number : 620003; 🇵🇹 Coimbra, Portugal

Investigational Site Number : 620004; 🇵🇹 Lisboa, Portugal

Investigational Site Number : 620009; 🇵🇹 Ponta Delgada, Portugal

Investigational Site Number : 151188; 🇷🇴 Cluj Napoca, Romania

Investigational Site Number : 642002; 🇷🇴 Cluj Napoca, Romania

Investigational Site Number : 642001; 🇷🇴 Cluj-Napoca, Romania

Investigational Site Number : 643001; 🇷🇺 Moscow, Russian Federation

Investigational Site Number : 643002; 🇷🇺 sait-Petersburg, Russian Federation

Investigational Site Number : 682002; 🇸🇦 Al Mubarraz, Saudi Arabia

Investigational Site Number : 682003; 🇸🇦 Jeddah, Saudi Arabia

Investigational Site Number : 682004; 🇸🇦 Makkah, Saudi Arabia

Investigational Site Number : 688001; 🇷🇸 Belgrade, Serbia

Investigational Site Number : 688002; 🇷🇸 Belgrade, Serbia

Investigational Site Number : 688003; 🇷🇸 Belgrade, Serbia

Investigational Site Number : 688005; 🇷🇸 Belgrade, Serbia

Investigational Site Number : 688004; 🇷🇸 NIŠ, Serbia

Investigational Site Number : 702001; 🇸🇬 Singapore, Singapore

Investigational Site Number : 703001; 🇸🇰 Bratislava, Slovakia

Investigational Site Number : 154138; 🇿🇦 Johannesburg, South Africa

Investigational Site Number : 710-003; 🇿🇦 Johannesburg, South Africa

Investigational Site Number : 150346; 🇿🇦 Sandton, South Africa

Investigational Site Number : 154119; 🇪🇸 Alcorcón, Madrid, Spain

Investigational Site Number : 153215; 🇪🇸 Seville, Sevilla, Spain

Investigational Site Number : 153219; 🇪🇸 Seville, Sevilla, Spain

Investigational Site Number : 154146; 🇪🇸 A Coruña, Spain

Investigational Site Number : 153237; 🇪🇸 Barcelona, Spain

Investigational Site Number : 154147; 🇪🇸 Barcelona, Spain

Investigational Site Number : 154163; 🇪🇸 Madrid, Spain

Investigational Site Number : 154236; 🇪🇸 Madrid, Spain

Investigational Site Number : 151524; 🇪🇸 Madrid, Spain

Investigational Site Number : 154199; 🇪🇸 Madrid, Spain

Investigational Site Number : 154160; 🇪🇸 Madrid, Spain

Investigational Site Number : 154145; 🇪🇸 Sabadell, Spain

Investigational Site Number : 154222; 🇪🇸 Santiago de Compostela, Spain

Investigational Site Number : 154205; 🇪🇸 Valencia, Spain

Investigational Site Number : 153213; 🇪🇸 Vigo, Spain

Investigational Site Number : 154238; 🇪🇸 Zaragoza, Spain

Investigational Site Number : 153216; 🇪🇸 Zaragoza, Spain

Investigational Site Number : 154095; 🇸🇪 Borås, Sweden

Investigational Site Number : 151726; 🇸🇪 Malmö, Sweden

Investigational Site Number : 154092; 🇸🇪 Norrköping, Sweden

Investigational Site Number : 157045; 🇨🇭 Bern, Switzerland

Investigational Site Number : 154093; 🇨🇳 Chiayi, Taiwan

Investigational Site Number : 152152; 🇨🇳 Hualien, Taiwan

Investigational Site Number : 152246; 🇨🇳 Kaohsiung City, Taiwan

Investigational Site Number : 152244; 🇨🇳 Kaohsiung, Taiwan

Investigational Site Number : 151534; 🇨🇳 New Taipei City, Taiwan

Investigational Site Number : 151500; 🇨🇳 Putz City, Chia-yi, Taiwan

Investigational Site Number : 151181; 🇨🇳 Taichung, Taiwan

Investigational Site Number : 151179; 🇨🇳 Taichung, Taiwan

Investigational Site Number : 153248; 🇨🇳 Tainan City, Taiwan

Investigational Site Number : 152153; 🇨🇳 Tainan City, Taiwan

Investigational Site Number : 151182; 🇨🇳 Taipei City, Taiwan

Investigational Site Number : 152226; 🇨🇳 Taipei City, Taiwan

Investigational Site Number : 152321; 🇨🇳 Taipei, Taiwan

Investigational Site Number : 153158; 🇨🇳 Taoyuan City, Taiwan

Investigational Site Number : 764003; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764004; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764001; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764005; 🇹🇭 Khon Kaen, Thailand

Investigational Site Number : 792006; 🇹🇷 Adana, Turkey

Investigational Site Number : 792005; 🇹🇷 Ankara, Turkey

Investigational Site Number : 792001; 🇹🇷 Ankara, Turkey

Investigational Site Number : 792002; 🇹🇷 Ankara, Turkey

Investigational Site Number : 792004; 🇹🇷 Istanbul, Turkey

Investigational Site Number : 792007; 🇹🇷 Izmir, Turkey

Investigational Site Number : 792003; 🇹🇷 Malatya, Turkey

Investigational Site Number : 7840001; 🇦🇪 Dubai, United Arab Emirates

Investigational Site Number : 151340; 🇬🇧 Cambridge, Cambridgeshire, United Kingdom

Investigational Site Number : 152287; 🇬🇧 Birmingham, United Kingdom

Investigational Site Number : 154240; 🇬🇧 Birmingham, United Kingdom

Investigational Site Number : 151646; 🇬🇧 London, United Kingdom

Investigational Site Number : 151123; 🇬🇧 London, United Kingdom

Investigational Site Number : 150303; 🇬🇧 London, United Kingdom

Investigational Site Number : 150455; 🇬🇧 Manchester, United Kingdom

Investigational Site Number : 152361; 🇬🇧 Salford, United Kingdom

Investigational Site Number : 154212; 🇻🇳 Hanoi, Vietnam

Investigational Site Number : 704002; 🇻🇳 Ho Chi Minh City, Vietnam