Review of Human Herpes Viruses in Burns

Completed

• Conditions: Herpes Simplex Virus; Cytomegalovirus; Burns; Chickenpox; Human Herpes Virus; Varicella-zoster Virus
• Interventions: Other: Review of the Literature for Human Herpes Virus infections

• Registration Number: NCT02452229
• Lead Sponsor: The University of Texas Medical Branch, Galveston

Brief Summary

Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Detailed Description

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"\[All Fields\] OR "herpes"\[All Fields\] OR "CMV"\[All Fields\] OR "cytomegalovirus"\[All Fields\] OR "VZV"\[All Fields\] OR "varicella-zoster"\[All Fields\]) AND ("burns"\[MeSH Terms\] OR "burns"\[All Fields\] OR "burn"\[All Fields\] OR "thermal trauma"\[All Fields\]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A\&HCI, CPCI-S.

Study Timeline

• Study Start: 2015-03
• Status Verified: 2015-05
• Primary Completion: 2015-05
• Study First Submitted: 2015-05-14
• Study First Submitted QC: 2015-05-19
• Last Update Submitted: 2015-05-19
• Study First Posted: 2015-05-22
• Last Update Posted: 2015-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10267

Inclusion Criteria

• Patients who presented with at least 1% TBSA burned
• Patients who presented with a viral infections during their hospitalization

Exclusion Criteria

• Patients who had no burns
• Patients who had no viral infections during their hospitalization

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Burn patients	Review of the Literature for Human Herpes Virus infections	The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.

Primary Outcome Measures

Name	Time	Method
Prevalence of Human Herpes Virus (HHV) Infections	Participants will be followed for the duration of hospital stay, an expected average of 3 months.	HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8

Secondary Outcome Measures

Name	Time	Method
Treatment of Human Herpes Virus (HHV) Infections	Participants will be followed for the duration of hospital stay, an expected average of 3 months.