Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on Knee Joint
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Plaque Psoriasis
- Sponsor
- MTI University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Neutrophils / Lymphocyte Ratio (Neutrophil-to-Lymphocyte Ratio)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Chronic plaque psoriasis, or psoriasis vulgaris, is a chronic inflammatory skin disease characterized by well demarcated, erythematous, scaly plaques on the extensor surfaces of the body and scalp. The lesions may occasionally itch or sting, and may bleed when injured. Dystrophic nail changes or nail pitting are found in more than one third of people with chronic plaque psoriasis, and psoriatic arthropathy occurs in 1% to more than 10%. The condition waxes and wanes, with wide variations in course and severity among individuals.
Detailed Description
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the challenging human immunodeficiency virus (HIV). Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs. Chronic plaque psoriasis is the most common form of psoriasis, accounting for more than 80% of cases. It is a chronic relapsing and remitting condition that presents as symmetrical, well-demarcated, erythematous thickened plaques with overlying silver scales. Appearance can vary depending on skin colour, ranging from pink on lighter skin to brown, purple, or grey on darker skin. It commonly affects the extensor surfaces (elbows and knees), scalp, trunk, and gluteal fold, but may arise on any part of the body. Plaques may coalesce to involve extensive areas of the skin, especially on the trunk and limbs.
Investigators
Ahmed Mohamed Ahmed Abd El hady El Fahl,ph.d
lectrurer of physical therapy for general surgery and dermatology
MTI University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Neutrophils / Lymphocyte Ratio (Neutrophil-to-Lymphocyte Ratio)
Time Frame: base line after 12 weeks
Ratio
(ESR) erythrocyte sedimentation rate
Time Frame: base line after 12 weeks
ESR
C-reactive protein (CRP)
Time Frame: base line after 12 weeks
A C-reactive protein (CRP) test measures the level of C-reactive protein in your blood.
Secondary Outcomes
- Isokinetic machine proprioceptive test(base line after 12 weeks)
- PASI score(base line after 12 weeks)