Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on Knee Joint
- Conditions
- Plaque Psoriasis
- Interventions
- Combination Product: Bee venom phonophoresis
- Registration Number
- NCT06106230
- Lead Sponsor
- MTI University
- Brief Summary
Chronic plaque psoriasis, or psoriasis vulgaris, is a chronic inflammatory skin disease characterized by well demarcated, erythematous, scaly plaques on the extensor surfaces of the body and scalp. The lesions may occasionally itch or sting, and may bleed when injured. Dystrophic nail changes or nail pitting are found in more than one third of people with chronic plaque psoriasis, and psoriatic arthropathy occurs in 1% to more than 10%. The condition waxes and wanes, with wide variations in course and severity among individuals.
- Detailed Description
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the challenging human immunodeficiency virus (HIV). Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs.
Chronic plaque psoriasis is the most common form of psoriasis, accounting for more than 80% of cases. It is a chronic relapsing and remitting condition that presents as symmetrical, well-demarcated, erythematous thickened plaques with overlying silver scales. Appearance can vary depending on skin colour, ranging from pink on lighter skin to brown, purple, or grey on darker skin. It commonly affects the extensor surfaces (elbows and knees), scalp, trunk, and gluteal fold, but may arise on any part of the body. Plaques may coalesce to involve extensive areas of the skin, especially on the trunk and limbs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group B:Bee venom topical application + Conservative care Bee venom phonophoresis Bee venom topical application + Conservative care (32 patients) Group A:Bee venom phonophoresis + Conservative care Bee venom phonophoresis Bee venom phonophoresis + Conservative care (32 patients) Group C:Conservative care Bee venom phonophoresis Control group Conservative care only (32 patients) Plain gel instead of BV gel plus off ultrasound (sham ultrasound) with medical treatment
- Primary Outcome Measures
Name Time Method Neutrophils / Lymphocyte Ratio (Neutrophil-to-Lymphocyte Ratio) base line after 12 weeks Ratio
(ESR) erythrocyte sedimentation rate base line after 12 weeks ESR
C-reactive protein (CRP) base line after 12 weeks A C-reactive protein (CRP) test measures the level of C-reactive protein in your blood.
- Secondary Outcome Measures
Name Time Method Isokinetic machine proprioceptive test base line after 12 weeks A dynamometer (System 3 Pro; Biodex Medical Inc., Shirley, NY, USA)
PASI score base line after 12 weeks Psoriasis area severity index (PASI), which evaluates the degree of erythema, induration, and desquamation in the affected body areas, is one of the most commonly used scales to classify disease severity
Trial Locations
- Locations (1)
Ahmed Mohamed Ahmed Abdelhady
🇪🇬Cairo, Egypt