Effect of micro-osteoperforations on rate of orthodontic tooth movement along with the evaluation of GCF biomarkers and alveolar bone density
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- to observe the rate of orthodontic tooth movement with micro-osteoperforations
研究概览
简要总结
This split-mouth design will compare the rate of orthodontic tooth movement with micro - osteoperforation. The study contains 30 subjects in experimental group . Three micro-osteoperforations will be performed with lance pilot drill, in the extraction site distal to canine just before retraction . The level of alveolar bone density will be measured at T1 (1 week) and T2 (1 month) time interval . The GCF biomarkers for orthodontic tooth movement will be measured at 0,7,14,21 and 28 days. The treatment duration will be of 4 months / till the completion of canine retraction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 17.00 Year(s) 至 30.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient with Angle’s Class I malocclusion, Angle’s Class I bimaxillary malocclusion and Class II bimaxillary and Angle’s class II div I malocclusion requiring 1st premolar extraction and bilateral maxillary canine ditalization were included
- •Only those patients were included in which atraumatic 1st premolar extraction was done.
- •The performance of MOPs and canine retraction was done at least 4 months after the extraction procedure to remove the bias due to the RAP induced due to extraction.
- •Canine roots to be in cancellous bone.
- •Patient with good oral hygiene.
排除标准
- •Patients on long term use of antibiotics, phenytoin, cyclosporine, anti-inflammatory drugs were discarded
- •Patients on systemic corticosteroids and calcium channel blockers were not included in the study.
- •Patients with history of periodontal therapy
- •Patients with untreated caries, gingivitis and h/o smoking were not included in the study.
结局指标
主要结局
to observe the rate of orthodontic tooth movement with micro-osteoperforations
时间窗: Total time period - 4 months | Patient will be recalled at every 7,14, 21, 28 days for first month and thereafter at every 28 days
次要结局
- To check the level of biomarkers at different time points and to assess the change in bone density level(0, 7,14, 21, 28 days)