Association Between Administration of Dexmedetomidine and Postoperative Mortality in Hospitals

Completed

• Conditions: In-hospital Mortality
• Interventions: Drug: Dexmedetomidine

• Registration Number: NCT06248346
• Lead Sponsor: Xijing Hospital

Brief Summary

The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals.

The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09-01
• Primary Completion: 2018-06-30
• Study Completion: 2018-07-01
• Status Verified: 2024-01
• Study First Submitted: 2024-01-24
• Study First Submitted QC: 2024-01-31
• Last Update Submitted: 2024-01-31
• Study First Posted: 2024-02-08
• Last Update Posted: 2024-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 518043

Inclusion Criteria

• adult patients (aged ≥18 years)
• undergo general anaesthesia with propofol
• from January 1, 2014 to June 30, 2018

Exclusion Criteria

• patients undergoing intervention procedures under monitored anaesthesia care (MAC)
• patients undergoing minor procedures under local or regional anaesthesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
dexmedetomidine	Dexmedetomidine	dexmedetomidine group: abbreviated for dexmedetomidine group, refers to the group with intraoperative administration of dexmedetomidine adjunct to propofol

Primary Outcome Measures

Name	Time	Method
in-hospital all-cause mortality	from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year	in-hospital deaths or discharged to hospice (or home)

Secondary Outcome Measures

Name	Time	Method
admission to the intensive care unit (ICU)	from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year	unplanned admissions
length of postoperative hospital stay	from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year	in days
adverse events after surgery	from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year	severe stroke, the necessity for renal replacement therapy (RRT), myocardial infarction, ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS), unplanned reoperation due to postoperative complications, sepsis, and multi-organ dysfunctions (MODs), if any