NCT03464175已完成不适用
Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation: a Randomized Comparative Scintigraphic Study
Cliniques universitaires Saint-Luc- Université Catholique de Louvain2 个研究点 分布在 1 个国家目标入组 34 人开始时间: 2018年1月22日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Quantity of aerosol deposition from the nebulizer reservoir to the subject. Measured by Planar scintigraphy.
研究概览
简要总结
The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years or older
- •Postoperative neurosurgery intubated patients admitted for brain neurosurgery in the ICU (Intensive care neuro-traumatologic and Toxicologic)- With a healthy lung function.
- •Signed and dated informed consent should be obtained in accordance of local regulations.
排除标准
- •Spine neurosurgery
- •History of cardiovascular and pulmonary disease
- •Extubation immediately after surgery
- •Modification of the allocated humidification technique before or during the nebulization (heated-humidifier deficiency or safety concern)
- •Inaccurate quantification of aerosol deposition (i.e., artifacts or overlap of tracheal and pulmonary deposition).
结局指标
主要结局
Quantity of aerosol deposition from the nebulizer reservoir to the subject. Measured by Planar scintigraphy.
时间窗: 45 minutes
% of the nominal dose.
次要结局
未报告次要终点
研究者
研究点 (2)
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