NCT00481442已完成2 期
Effects of Phenylephrine on Systemic and Regional Hemodynamics in Patients With Septic Shock: a Crossover Pilot Study
University of Roma La Sapienza2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2007年1月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Systemic and regional hemodynamics
研究概览
简要总结
Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clical diagnosis of Septic Shock
- •norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg).
排除标准
- •Age < 18 years
- •Pregnancy
- •Present or suspected acute coronary artery disease
- •Present or suspected acute mesenteric ischemia.
结局指标
主要结局
Systemic and regional hemodynamics
时间窗: 24 hours
次要结局
- Organ functions, adverse effects(24 hours)
研究者
研究点 (2)
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