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临床试验/CTRI/2024/04/066387
CTRI/2024/04/066387已完成2/3 期

Efficacy of Murivenna Bandage and Agnikarma in the Management of Snayugata Vata (Carpal tunnel syndrome)-An Open Labelled Randomised Comparative Clinical Trial

Institute of Teaching and Research in Ayurveda, Jamnagar1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年6月17日最近更新:

试验速览

阶段
2/3 期
状态
已完成
发起方
入组人数
30
试验地点
1
主要终点
1. Reduction of pain at hand

研究概览

简要总结

The clinical study titled “Efficacy of Murivenna Bandage and Agnikarma in the Management of Snayugata Vata (Carpal Tunnel Syndrome)” was an open-labelled, randomized comparative trial conducted on 30 patients diagnosed with Carpal Tunnel Syndrome (CTS). Participants were divided into two groups: Group A received Murivenna bandaging once weekly for four weeks, and Group B underwent Agnikarma at the tender points of the wrist for the same duration. The assessment included both subjective parameters (pain, Tinel’s sign, Phalen’s test, carpal compression test, and Boston CTS Questionnaire) and objective measures (nerve conduction study and wrist range of motion). Demographic analysis revealed a predominance of females (79%), mostly postmenopausal housewives from the middle socioeconomic class, with the majority aged between 51–60 years. The right hand was more frequently affected, and most patients had symptoms for less than six months with gradual onset.

Both Murivenna bandage and Agnikarma showed highly significant improvements (P < 0.001) in all subjective and objective parameters, including pain relief, CTS test outcomes, nerve conduction velocity, and wrist mobility. Comparative analysis between the two groups demonstrated no statistically significant difference in most parameters, indicating that both therapies were equally effective. However, the Functional Severity Scale of the Boston Questionnaire (P = 0.018) and palmar flexion range of motion (P = 0.023) showed significant differences, suggesting slightly superior functional improvement with Agnikarma. Both interventions provided relief from pain, tingling, and numbness, and improved wrist movements. Murivenna bandage was more effective in acute inflammatory and traumatic conditions, whereas Agnikarma produced better outcomes in chronic pain cases. Seasonal variation was also noted—Murivenna was more effective during the hot season, while Agnikarma showed better results in the cold season. Both treatments were cost-effective, minimally invasive, non-pharmacological, and suitable for outpatient management, with no adverse effects reported during the study or follow-up. Hence, the null hypothesis was accepted, confirming that Murivenna bandage and Agnikarma are equally effective in the symptomatic management of Snayugata Vata (Carpal Tunnel Syndrome).

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Inclusion Criteria:
  • Patients suffering from Snayugata Vata (carpal tunnel syndrome)
  • Patients with age group 18-60 years irrespective of sex, religion, occupation, socio-economic status.

排除标准

  • Exclusion Criteria:
  • Patients of with/without Hypertension (BP above 140/90mmHg) and has Diabetes mellitus with uncontrolled RBS (above 150mg/dl) due to vulnerability.
  • Patients with K/C/O paralysis, Parkinson’s disease, cardiac diseases, renal diseases, endocrine diseases, severe anemia, polyneuropathy and malignancy.
  • Pregnant and lactating females.
  • Patients contraindicated for Agnikarma and Bandhana as per classics.

结局指标

主要结局

1. Reduction of pain at hand

时间窗: day 1 and day 28

2. Reduction of numbness at hand

时间窗: day 1 and day 28

3. Reduction of tingling sensation at hand

时间窗: day 1 and day 28

次要结局

  • Absence of recurrence in the follow up period.(day 60)

研究者

发起方
Institute of Teaching and Research in Ayurveda, Jamnagar
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Esha Ebrahim

Institute of Teaching and Research in Ayurveda, Jamnagar

研究点 (1)

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