Sparsity-based Magnetic Resonance Imaging of Cardiac Arrhythmias
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Paired-sample t tests for quantitative measures of intensity of image artifacts
研究概览
简要总结
The primary purpose of this study is to improve the quality of Magnetic Resonance Imaging in patients with heart arrhythmia. Investigators will recruit 105 patients with arrhythmia and 30 control volunteers over 3 years and will use two arrhythmia-tolerant imaging methods for diagnosis.
详细描述
In the proposed research, investigators will extend conventional cardiac magnetic resonance methods to enable the creation of high-quality cine CMR images in the presence of multiple kinds of arrhythmia. Two arrhythmia-tolerant imaging methods will be adopted, which are particularly useful in arrhythmia: 1) 3D imaging, which is useful for many purposes, including "road mapping" of electrophysiology (EP) procedures, and 2) late gadolinium enhancement (LGE), which is useful for delineating abnormal myocardium, including fibrotic regions that can serve as sources of arrhythmias.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 85 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for Arrhythmia Patients:
- •Patients diagnosed with heart arrhythmia scheduled for routine clinical MRI examinations).
- •Patients scheduled for routine clinical MRI examinations who do not have a specific known diagnosis of arrhythmia, but who may be found to have image degradation due to arrhythmia during the CMR examination.
- •Inclusion Criteria for Controls:
- •No history of heart arrhythmia.
排除标准
- •for Patients and Controls:
- •Hemodynamic instability.
- •Contraindications for MRI examinations (e.g., pacemakers or ferromagnetic vascular clips).
- •History of prior cardiovascular disease or significant risk factors:
- •Diabetes, hypertension, smoking, and hyperlipidemia, etc.
研究组 & 干预措施
Patients with Arrhythmias
干预措施: 3D Imaging (Other)
Patients with Arrhythmias
干预措施: Late Gadolinium Enhancement (LGE) (Other)
Healthy Control
干预措施: 3D Imaging (Other)
Healthy Control
干预措施: Late Gadolinium Enhancement (LGE) (Other)
结局指标
主要结局
Paired-sample t tests for quantitative measures of intensity of image artifacts
时间窗: 3 Years
Paired-sample Wilcoxon signed rank test to evaluate measures on Likert scales
时间窗: 3 Years
次要结局
未报告次要终点