A prospective observational study on the efficacy of switching to sertraline in depressive patients who failed treatment with duloxetine
Not Applicable
Recruiting
- Conditions
- major depressive disorder
- Registration Number
- JPRN-UMIN000009609
- Lead Sponsor
- Tokyo Womens Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
Comorbidity of alcohol and/or drug abuse Presence of psychosis Intolerant to sertraline Required prohibited concomitant therapy (to be described) Pregnant women women suspected of being pregnant or breastfeeding Serious or unstable medical illness Judged to be at risk by the investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy rate of switching from duloxetine to sertraline using CGI-I, HAM-D, patient rating scales (CES-D)
- Secondary Outcome Measures
Name Time Method Epigenetic changes before and after sertraline treatment Baseline clinical, genetic, and epigenetic and metabolome factors in sertraline responders compared to those of non-responders Baseline clinical, genetic, and epigenetic and metabolome factors in sertraline remitters compared to those of non-remitters