Serial, integrated, non-invasive mapping of electro-mechanical activation of the human heart under various pacing conditions.
Completed
- Conditions
- heart failureheart rhythm disorder10082206
- Registration Number
- NL-OMON40063
- Lead Sponsor
- HagaZiekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Humans of at least 18 years old
Cardiac conduction disorder for which implantation of pacemaker is indicated
Rhythm disorders for which electrophysiological examination is performed.
Exclusion Criteria
Humans younger than 18 years old.
Individuals not capable of providing informed consent.
Women of child bearing age and not on reliable birth control program/pregnant women.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The altered pathway of electrical and mechanical activation of the human heart<br /><br>and the accompanying hemodynamic response.<br /><br><br /><br>Electrical activation:<br /><br>Electrical activation patterns of the human heart. Periods of conduction<br /><br>(pq-time, qrs-duration, qtc-time).<br /><br><br /><br>Mechanical activation:<br /><br>Left ventricle (LV) contraction pattern. LV ejection fraction, stroke volume,<br /><br>end-diastolic pressure and volume of left ventricle.<br /><br><br /><br>Hemodynamics of patient during study.<br /><br><br /><br>Quality of life during study.<br /><br><br /><br>Cardiac Electrical activation times registered simultaneously during EPS in<br /><br>patients suffering from arrhythmias and in individuals in whom structural heart<br /><br>disease is ruled out.<br /><br><br /><br>Atrial scar in patients after ablation therapy.</p><br>
- Secondary Outcome Measures
Name Time Method <p>(serious) adverse events</p><br>