Aerobic Interval Training in Patients With Paroxysmal or Persistent Atrial Fibrillation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 51
- Locations
- 2
- Primary Endpoint
- Change in burden of atrial fibrillation
Study Overview
Brief Summary
The purpose of this study is to determine the effect of aerobic interval training in patients with paroxysmal or persistent atrial fibrillation, especially to see if the burden of atrial fibrillation and symptoms are reduced.
Detailed Description
Long term endurance sport practice is associated with a higher incidence of atrial fibrillation. Moderate/light physical activity seems to be associated with a lower incidence. The underlying mechanisms are uncertain. In order to examine the effect of training in this population, the investigators will perform a randomised controlled study with aerobic interval training in patients with paroxysmal/persistent atrial fibrillation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with paroxysmal or persistent atrial fibrillation, that are able to perform aerobic interval training.
Exclusion Criteria
- •Performing high intensity training (pulse >90% of max) for more than 2 times a week.
- •Moderate intensity training more than 30 min, more than 3 times a week
- •Previous open heart surgery
- •Significant aorta stenosis
- •Mitral insufficiency, >gr. 2
- •Pacemaker
- •Earlier coronary intervention and not complete revascularization
Outcomes
Primary Outcomes
Change in burden of atrial fibrillation
Time Frame: Baseline and 4 weeks after ended intervention period
Burden of atrial fibrillation(number of episodes, duration(percent of the day)) continually measured, and reported by the patient. Analysed for the patients in total, with sub analysis in the groups of paroxysmal and persistent AF and in those with a low burden of atrial fibrillation vs. those with a larger burden.
Secondary Outcomes
- Size of left atrium and ventricle(Baseline and after ended intervention period(12 weeks))
- Blood samples(Baseline and after ended intervention period(12 weeks))
- Endothelial function(Baseline and after ended intervention period(12 weeks))
- Atrial extrasystoles(Baseline and after ended intervention period(12 weeks))
- Ablation procedure(Measured during the ablation procedure (day 1))
- Maximal oxygen uptake(Baseline and after ended intervention period(12 weeks))
- Atrial and ventricular function(Baseline and after ended intervention period(12 weeks))
- Fibrosis(Baseline and after ended intervention period(12 weeks))
- Quality of life(Baseline and after ended intervention period(12 weeks))
- Burden of atrial fibrillation in the intervention period(Week 1-4, 5-8 and 9-12)