Lateral Lymph Node Dissection for Middle-low Rectal Cancer
- Conditions
- Rectal Cancer
- Interventions
- Radiation: CT three-dimensional reconstruction
- Registration Number
- NCT03826862
- Lead Sponsor
- Ziqiang Wang,MD
- Brief Summary
The investigators will perform CT three-dimension reconstruction for middle-low rectal cancer patients who have enlarged lateral lymph nodes to recognize the variance of pelvic vessels, by which to help reduce operative time and blood loss, localize the lateral lymph nodes, improve the lymph node harvested and positive rate. Besides, The investigators will label the vessels near the interested node to achieve node-by-node for further investigation.
- Detailed Description
CT three-dimensional reconstruction was performed for middle-low patients who had enlarged lateral lymph node before surgery. The main purpose is to recognize the track and variance of pelvic and iliac blood vessels. The investigators want to explore whether this method can help reduce operative time, unexpected injuries and blood loss, and The investigators also want to study whether it can help improve the lymph node harvested and positive rate during lateral lymph node dissection. Besides, The investigators want to perform node-by-node for enlarged lateral lymph node and CT three-dimensional reconstruction can help the investigators to localize and label the interested lymph node during operation. After node-by-node, The investigators can explore the accuracy of radiologists' and surgeons' judgement for lateral lymph node metastasis, and The investigators also want explore the best cut-off value of shorter diameter to predict lateral lymph node metastasis. Besides, The investigators want to perform texture analysis by combination radiology and pathology to find some useful parameters to predict lateral lymph node metastasis.
The investigators also want to explore the feasibility of dissecting the unilateral visceral branch of internal iliac vessels when performing lateral lymph node dissection.
The investigators will have a close follow-up for patients who have enlarged lateral lymph node but do not meet the criteria for lateral lymph node dissection. CT three-dimensional reconstruction can help The investigators recognize which parts' lateral lymph nodes have more potential possibility to metastasis and recurrence.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- confirmed rectal cancer; 2) tumor located less than 10 cm from the anus verge; 3) have enlarged lateral lymph on preoperative CT/MRI
- patients who have severe liver or renal dysfunction;
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description intervention group CT three-dimensional reconstruction All patients receive CT three-dimensional reconstruction before surgery.
- Primary Outcome Measures
Name Time Method operative time 2 year including total operative time and that for lateral lymph node
Blood loss 2 year intraoperative blood loss
lateral lymph node harvested 2 year lateral lymph node harvested
Cut-off value of shorter diameter 2 year The best cut-off value of shorter diameter for lateral lymph node dissection
postoperative complication 2 year including urinary and sexual function
Accuracy of judgement for lateral lymph node metastasis 2 year including radiologists' and surgeons' accuracy
vessels variances October 1. 2018-December 31.2020 The blood vessels variance of internal iliac vessels
- Secondary Outcome Measures
Name Time Method overall survival 3 year overall survival
local recurrence rate 3 year local recurrence rate
disease-free survival 3 year disease-free survival
Trial Locations
- Locations (1)
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China