Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer
Overview
- Phase
- Not Applicable
- Intervention
- PET-MRI
- Conditions
- Esophagogastric Cancer
- Sponsor
- University Health Network, Toronto
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors
- Status
- Recruiting
- Last Updated
- last month
Overview
Brief Summary
This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided.
The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients 18 years or older
- •Diagnosed with locally advanced esophageal cancer being considered for conventional RT \>4 weeks
- •Ability and willingness to provide written informed consent
Exclusion Criteria
- •Contraindication for MRI
- •Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
- •Any patient who is pregnant or breastfeeding
- •Pacemaker or implanted defibrillator
- •Claustrophobia
Arms & Interventions
PET-MRI
PET-MRI in esophagogastric cancers
Intervention: PET-MRI
Outcomes
Primary Outcomes
Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors
Time Frame: 2 years
Detection of metastases on DWI and gadolinium enhanced T1-weighted 3D VIBE sequences.
Secondary Outcomes
- Difference in manual GTV segmentation using PET-MRI(2 years)
- Quantification of dosimetric advantages of PET-MRI treatment plan(2 years)